Related Experiment Video

Updated: Jan 29, 2026

Generation of Induced Pluripotent Stem Cells from Turner Syndrome 45XO Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome
09:39

Generation of Induced Pluripotent Stem Cells from Turner Syndrome 45XO Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome

Published on: December 4, 2021

3.5K

Microcornea, posterior megalolenticonus, persistent fetal vasculature, chorioretinal coloboma (MPPC) syndrome: Case

Lindsay D Rothfield1, Linda A Cernichiaro-Espinosa2,3, Chrisfouad R Alabiad2

  • 1University of Miami Miller School of Medicine, 1600, NW 10th Ave, Miami, FL, United States.

American Journal of Ophthalmology Case Reports
|February 16, 2019
PubMed
Abstract

Insights

This study shows that surgical intervention, including pars plana vitrectomy and lensectomy, can improve vision and function in patients with microcornea, persistent fetal vasculature (PFV), and related conditions.

Area of Science:

  • Ophthalmology
  • Genetics
  • Surgical Innovation

Background:

  • Microphthalmia with corneal opacity, persistent fetal vasculature (PFV), chorioretinal coloboma, and megalolenticonus (MPPC) syndrome is a rare condition.
  • Variations of MPPC syndrome present unique challenges in visual rehabilitation.
  • Surgical management of complex pediatric ocular conditions requires careful consideration of functional outcomes.

Purpose of the Study:

  • To report on three patients with a variation of MPPC syndrome.
  • To evaluate the efficacy of pars plana vitrectomy, pars plana lensectomy, and amblyopic management in these patients.
  • To compare clinical characteristics and surgical outcomes with existing literature.

Main Methods:

  • Retrospective review of medical records for patients with microcornea, PFV, chorioretinal coloboma, and microphthalmia.
  • Surgical correction involving pars plana vitrectomy and lensectomy was performed.
  • Ancillary tests included color fundus photography, fluorescein angiography, and echography.

Main Results:

  • Three patients (6 eyes) were included in the study.
  • Four eyes underwent surgical intervention.
  • Post-surgical intervention, patients showed improved visual acuity and functional status.

Conclusions:

  • Surgical intervention can benefit patients with microcornea, PFV, chorioretinal coloboma, and microphthalmos, especially with functional decline or media opacities.
  • Despite challenges in pre- and post-operative visual acuity assessment, functional and visual improvements were evident.
  • This study highlights the potential for positive outcomes with timely surgical management in complex cases.

More Related Videos

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes09:20

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

Published on: February 8, 2018

11.4K
Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure10:07

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

Published on: March 20, 2012

27.0K

Related Concept Videos

Resistors In Series01:10

Resistors In Series

A resistor is an ohmic device that limits the flow of charge in a circuit. Most circuits have more than one resistor. If several resistors are connected together and connected to a battery, the current supplied by the battery depends on the equivalent resistance of the circuit. The equivalent resistance of a combination of resistors depends on both their individual values and how they are connected. The simplest combination of resistors is the series combination. 
In a series circuit, the...
6.4K
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
2.8K
Series Resonance01:17

Series Resonance

The RLC circuit impedance is defined as the ratio of the supply voltage to the circuit current. Resonance in such a circuit occurs when the imaginary part of this impedance equals zero. This specific condition means that the inductive reactance is exactly equal to the capacitive reactance. The frequency at which this happens is known as the resonant frequency. Mathematically, the resonant frequency is inversely proportional to the square root of the product of the inductance (L) and capacitance...
799
Series and Parallel Capacitors01:14

Series and Parallel Capacitors

Capacitors, fundamental components in electronic circuits, can be connected in series and/or parallel configurations. Each configuration has different impacts on the overall behavior of the circuit.
First, consider capacitors connected in series to a battery. In this configuration, the plate connected to the battery's positive terminal develops a positive charge, while the plate attached to the negative terminal becomes negatively charged. An equal magnitude of charge is induced on the...
9.3K
Trigonometric Fourier series01:17

Trigonometric Fourier series

Fourier series is a foundational mathematical technique that decomposes periodic functions into an infinite series of sinusoidal harmonics. This method enables the representation of complex periodic signals as sums of simple sine and cosine functions, facilitating their analysis and interpretation in various fields, including signal processing, acoustics, and electrical engineering.
The trigonometric Fourier series specifically expresses a periodic function with a defined period T using sine...
792
Convergence of Fourier Series01:21

Convergence of Fourier Series

The Fourier series is a powerful mathematical tool for representing periodic signals as an infinite sum of complex exponentials. In practice, this infinite series is truncated to a finite number of terms, yielding a partial sum. This truncation makes the approximation of the signal feasible but introduces certain challenges, particularly near discontinuities, known as the Gibbs phenomenon.
The Gibbs phenomenon refers to the persistent oscillations and overshoots that occur near discontinuities...
400