Status of Measles Elimination in Eleven Countries with High Routine Immunisation Coverage in The WHO African Region

Balcha Masresha1, Richard Luce2, Messeret Shibeshi3

  • 1WHO Regional Office for Africa, Brazzaville, Congo.

Journal of Immunological Sciences
|February 16, 2019
PubMed
Abstract

Insights

High measles vaccination coverage is essential for elimination. However, 11 countries assessed showed program gaps, indicating they are not yet ready for measles elimination verification. Addressing these gaps is crucial for future success.

Area of Science:

  • Public Health
  • Epidemiology
  • Vaccinology

Background:

  • Measles elimination requires sustained absence of endemic transmission and robust surveillance.
  • The World Health Organization (WHO) mandates country-level verification for measles and rubella elimination.
  • High vaccination coverage is a prerequisite for achieving and verifying measles elimination.

Purpose of the Study:

  • To evaluate the readiness of 11 high-performing countries for measles elimination verification.
  • To assess programmatic parameters beyond first-dose measles vaccination coverage.
  • To identify specific gaps hindering the verification process.

Main Methods:

  • Identified 11 countries with over 90% measles-first-dose (MCV1) coverage for five years (WHO-UNICEF estimates).
  • Analyzed MCV1 and second-dose (MCV2) vaccination coverage rates.
  • Assessed performance in supplemental immunization activities (SIAs) and case-based surveillance.

Main Results:

  • Six countries (Algeria, Botswana, Gambia, Mauritius, Rwanda, Seychelles) maintained MCV1 coverage >=95% since 2011.
  • In 2015, only three countries achieved >=95% MCV2 coverage.
  • Supplemental immunization activities showed variable success, with only 6 of 22 activities achieving <95% coverage.
  • Only Rwanda and Lesotho met all surveillance targets for five consecutive years.

Conclusions:

  • Despite high routine MCV1 coverage, all 11 countries exhibit programmatic gaps preventing immediate measles elimination verification.
  • Establishing national verification committees is recommended to document progress and address identified gaps.
  • Continued efforts are needed to strengthen immunization programs and surveillance systems for eventual verification.

Related Concept Videos

IR Frequency Region: Fingerprint Region01:03

IR Frequency Region: Fingerprint Region

IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
1.9K
Marcia's Theory of Identity Status01:26

Marcia's Theory of Identity Status

James Marcia's identity status model provides a framework for understanding how adolescents navigate identity formation through varying degrees of exploration and commitment. Marcia's model builds on Erik Erikson's theories of psychosocial development, focusing specifically on how adolescents reconcile individual aspirations with societal expectations. His model describes identity formation as a dynamic process where adolescents move between different states depending on their level...
1.6K
Elimination Kinetics: First-Order and Zero-Order01:05

Elimination Kinetics: First-Order and Zero-Order

Eliminating drugs from the body is a vital process that occurs through excretion or metabolism. Understanding the kinetics of drug elimination is crucial for drug development, dosage determination, and optimizing patient outcomes.
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is a drug's half-life, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
2.8K
Elimination Reactions02:25

Elimination Reactions

A nucleophile can react with an alkyl halide to give the substitution product by displacing the halogen. Or it can function as a base to give the elimination product by deprotonation of the neighboring carbon to form an alkene. In an elimination reaction, the substrate loses two groups from adjacent carbons forming at least one π bond. The carbon attached to the halogen is called the α carbon, while the adjacent carbon is called the β carbon; hence, these reactions are called...
16.9K
Radical Formation: Elimination00:51

Radical Formation: Elimination

Another method of radical formation is the elimination process. It is the opposite of the addition route and is driven by the instability of the radical. For example, as depicted in Figure 1, dibenzoyl peroxide yields a pair of unstable radicals upon homolysis. Given its instability, this radical spontaneously undergoes elimination via a C–C bond cleavage to form a relatively more stable phenyl radical. The mechanism involves cleavage of the bond between the α and β positions with respect...
2.4K
Gaussian Elimination: Problem Solving01:30

Gaussian Elimination: Problem Solving

Systems of linear equations in several variables are pivotal in modeling complex scenarios involving multiple unknowns and constraints. Such systems are widely used in various fields to represent relationships where several conditions must be simultaneously satisfied. Each variable in the system corresponds to an unknown quantity, while each equation imposes a linear constraint, leading to a structured approach for analyzing and solving real-world problems.A system of three equations with three...
183