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Updated: Jan 29, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
[General practitioner density is not associated with survival in patients with hepatocellular carcinoma]
Insights
General practitioner (GP) density did not impact hepatocellular carcinoma (HCC) patient survival or diagnosis stage in a French region. This study found no significant difference in outcomes based on proximity to healthcare providers for HCC patients.
Area of Science:
- Oncology
- Public Health
- Health Services Research
Background:
- Hepatocellular carcinoma (HCC) is a significant global health concern.
- Access to primary care, indicated by general practitioner (GP) density, may influence cancer patient outcomes.
- Understanding geographic healthcare disparities is crucial for improving cancer care delivery.
Purpose of the Study:
- To investigate the association between general practitioner (GP) density and overall survival in hepatocellular carcinoma (HCC) patients.
- To determine if GP density affects the stage of HCC at initial diagnosis.
- To analyze the impact of primary care accessibility on HCC patient outcomes in a specific French region.
Main Methods:
- Retrospective analysis of 246 consecutive HCC patients from 2012-2016.
- Data collected included clinico-biological, radiological, GP density in residence area, and HCC stage.
- Survival analysis performed using Kaplan-Meier method and log-rank test.
Main Results:
- No statistically significant difference in overall survival between patients in low GP density areas (median 11.7 months) and high GP density areas (median 14.8 months).
- Tumor stage at initial diagnosis and time to multidisciplinary meeting presentation were similar across different GP density levels.
- 20.7% of patients resided in low GP density areas (2.2-6.8 GPs/10000 inhabitants).
Conclusions:
- General practitioner density in a patient's residential area does not significantly influence overall survival for hepatocellular carcinoma (HCC) patients.
- GP density did not correlate with the stage of HCC at the time of initial diagnosis in this cohort.
- Healthcare accessibility, as measured by GP density, may not be a determining factor for HCC outcomes in this specific North-Eastern French region.
Objective:
To determine if the density of general practitioners (GPs) had an impact on overall survival of patients with hepatocellular carcinoma (HCC) and stage of HCC at initial diagnosis in a North-Eastern region of France.
Methods:
This retrospective study was performed with 246 consecutive HCC patients referred to a multidisciplinary meeting dedicated to hepatobiliary tumors in the Reims University Hospital from 2012 to 2016. The following data were collected: clinico-biological and radiological data, GP density in patient residence area, stage of HCC at diagnosis, treatment. Survival curves were calculated by Kaplan-Meier method and compared with log-rank test.
Results:
Fifty-one patients (20.7%) were living in a low GP density area (2.2 to 6.8 GPs/10000 inhabitants) and 195 (79.3%) in a high GP density area (6.8 à 12.6 GPs/10000 inhabitants). Overall survival of patients living in a low GP density area was not statistically different from that of patients living in a high GP density area (median survival of 11.7 and 14.8 months respectively; p = 0.58). The tumor stage at initial diagnosis and the delay between diagnosis and case presentation at the multidisciplinary meeting were not significantly different between high and low GP density areas.
Conclusion:
In a cohort of patients with HCC referred to a regional multidisciplinary meeting dedicated to hepatobiliary cancers, the GP density in residence area of patients with HCC did not influence significantly their survival nor the stage of HCC at diagnosis.
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