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Red and NIR Light-Responsive Polymeric Nanocarriers for On-Demand Drug Delivery

Xinyu He^1,2,3, Xianzhu Yang¹, Dongdong Li¹

¹Institutes for Life Sciences, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.

Current Medicinal Chemistry

|February 16, 2019

Abstract:

Red and NIR light-responsive polymeric nanocarriers capable of on-demand drug delivery have gained tremendous attention for their great potential in cancer therapy. Various strategies have been applied to fabricate such nanocarriers, and they have demonstrated significant therapeutic efficacy and minimal toxicity to normal tissues. Here, we will review the current developments in various red and NIR light-responsive polymeric nanocarriers with respect to their use in on-demand drug delivery, including facilitation of drug internalization and boosting of drug release at targeted sites. We summarize their components and design strategies, and highlight the mechanisms by which the photoactivatable variations enhance drug uptake and drug release. We attempt to provide new insights into the fabrication of red and NIR light-responsive polymeric nanocarriers for on-demand drug delivery.

Keywords:

NIR light Polymeric nanocarriers drug delivery drug release photodynamic therapy photothermal therapy red light.

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