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A multicellular rosette-mediated collective dendrite extension.

Li Fan1, Ismar Kovacevic1, Maxwell G Heiman2,3

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Neurons in C. elegans sensory organs extend dendrites collectively. Epidermal pulling guides this process, involving adhesion molecules and PAR-6, revealing a novel neurite extension mechanism.

Keywords:
C. eleganscollective cell behaviordendrite morphogenesismulticellular rosetteneuron-epicermis interactionneuroscienceorganogenesissensory organ

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Neurite morphogenesis is essential for neural circuit formation.
  • Cellular and molecular mechanisms of neurite extension are not fully understood.

Purpose of the Study:

  • To investigate the collective dendrite extension mechanism in C. elegans amphid neurons.
  • To identify molecular players involved in neurite extension and tissue interaction.

Main Methods:

  • Utilized C. elegans as a model organism.
  • Observed neuronal rosette formation and dendrite extension.
  • Analyzed the function of adhesion molecules (DYF-7, SAX-7, HMR-1, DLG-1) and PAR-6.

Main Results:

  • Amphid neurons form a multicellular rosette, with dendrite tips attached to migrating epidermis.
  • Epidermal migration extrudes dendrites away from cell bodies.
  • DYF-7, SAX-7, HMR-1, and DLG-1 redundantly mediate rosette-epidermis attachment.
  • PAR-6 at the rosette vertex promotes DYF-7 localization and dendrite extension.

Conclusions:

  • Neurite extension can occur via a collective mechanism, distinct from the pioneer-follower model.
  • Mechanical cues from surrounding tissues play a critical role in shaping neurites.
  • This study reveals novel insights into the coordination of neurite morphogenesis and tissue interactions.