Functional brain connectivity in electrical status epilepticus in sleep.
Steven H Mott1, Richard P Morse2, Scott A Burroughs2
1Department of Pediatrics, University of California, Irvine.
Epileptic Disorders : International Epilepsy Journal with Videotape
|February 16, 2019
Summary
Electrical status epilepticus in sleep (ESES) causes high EEG coherence during sleep. This study found increased brain signal consistency in children with ESES, potentially linking to cognitive issues.
Area of Science:
- Neuroscience
- Epileptology
- Pediatric Neurology
Background:
- Electrical status epilepticus in sleep (ESES) is an age-related epileptic encephalopathy.
- ESES presents with cognitive/behavioral issues and specific EEG patterns during sleep.
- The impact of sleep epileptiform discharges on cognition is not fully understood.
Purpose of the Study:
- To investigate EEG coherence alterations during slow-wave sleep in children with ESES.
- To compare EEG coherence in ESES patients during and outside of ESES periods.
- To compare EEG coherence in children with ESES versus typically developing children.
Main Methods:
- Analyzed EEG coherence during slow-wave sleep in children with ESES and controls.
- Compared coherence during ESES epochs versus non-ESES epochs.
- Examined coherence across various bandwidths and electrode pairs.
Main Results:
- Children with ESES exhibited significantly higher EEG coherence across all bandwidths and electrode pairs.
- Elevated coherence was observed both during ESES events and in inter-discharge periods.
- High coherence was linked to spike-and-wave discharges but also present between them.
Conclusions:
- EEG coherence is markedly increased during ESES in affected children.
- Further research is needed to correlate these coherence changes with observed cognitive and behavioral abnormalities.
Keywords:
EEGcoherencecontinuous spike and waves during slow wave sleep (CSWS)electrical status epilepticus in sleep (ESES)oscillationsphase lagMore Related Videos
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