Global prevalent use, trends and practices in haemodiafiltration

Area of Science:

• Nephrology
• Renal Replacement Therapy
• Epidemiology

Background:

• Online haemodiafiltration (HDF) is an advanced renal replacement therapy (RRT).
• Clinical trials suggest HDF superiority over conventional haemodialysis with adequate convective dose.
• Understanding HDF's global prevalence and trends is crucial for RRT advancement.

Purpose of the Study:

• To report on the current global prevalence and epidemiological trends of HDF.
• To analyze HDF prescription patterns and factors influencing its clinical acceptance and implementation.
• To provide an overview based on consolidated data from market surveys and national registries.

Main Methods:

• Analysis of international end-stage kidney disease data from an annually updated database.
• Utilizing market survey data, national renal registries, and recent study databases.
• Examining patient growth rates and comparing HDF trends with overall haemodialysis (HD) growth.

Main Results:

• Online HDF acceptance is rapidly growing in Europe and Asia Pacific, with patient growth rates of 12-24%.
• HDF growth significantly outpaces the total patient haemodialysis (HD) growth rate of 6.6%.
• Data collection challenges exist in national and international renal registries.

Conclusions:

• Online HDF represents a paradigm shift in RRT with promising clinical outcomes.
• Growing acceptance suggests HDF may become a new standard of care for end-stage kidney disease patients globally.
• Further initiatives may accelerate HDF adoption worldwide.