Related Experiment Video

Updated: Jan 29, 2026

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
08:29

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel

Published on: May 14, 2018

10.5K

CanStem111P trial: a Phase III study of napabucasin plus nab-paclitaxel with gemcitabine

Mohamad Bassam Sonbol1, Daniel H Ahn1, David Goldstein2

  • 1Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ 85054, USA.

Future Oncology (London, England)
|February 16, 2019
PubMed

Insights

Napabucasin, an investigational oral agent, was studied in combination with standard chemotherapy for advanced pancreatic cancer. This trial assessed its efficacy and safety as a first-line treatment option.

Area of Science:

  • Oncology
  • Clinical Trials
  • Drug Development

Background:

  • Napabucasin is an investigational oral agent targeting multiple oncogenic pathways.
  • Metastatic pancreatic adenocarcinoma remains a significant challenge in cancer treatment.

Purpose of the Study:

  • To evaluate the efficacy and safety of napabucasin combined with nab-paclitaxel and gemcitabine.
  • To determine the role of napabucasin in the first-line treatment of metastatic pancreatic cancer.

Main Methods:

  • A multicenter, randomized, open-label, Phase III clinical trial (CanStem111P).
  • Patients received weekly gemcitabine and nab-paclitaxel with or without napabucasin (1:1 randomization).

Main Results:

  • The study aimed to determine the efficacy and safety of the combination therapy.
  • Results will inform the clinical utility of napabucasin in advanced pancreatic cancer management.

Conclusions:

  • The CanStem111P trial will provide crucial data on napabucasin's potential in treating metastatic pancreatic cancer.
  • Findings will help define the role of this novel agent in the therapeutic landscape.
Keywords:
BBI-608CanStem111Pcancer stem cellsnapabucasinpancreatic adenocarcinoma

More Related Videos

Assessing Two-dimensional Crystallization Trials of Small Membrane Proteins for Structural Biology Studies by Electron Crystallography09:23

Assessing Two-dimensional Crystallization Trials of Small Membrane Proteins for Structural Biology Studies by Electron Crystallography

Published on: October 29, 2010

11.6K
Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes07:45

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes

Published on: May 1, 2021

3.2K

Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.9K
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
403
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
353
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.4K
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
484
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
408