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Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Renal Replacement Therapy

Background:

  • Acute kidney injury (AKI) incidence is increasing in critically ill patients.
  • AKI is associated with significant morbidity and mortality.
  • Renal replacement therapy (RRT) can be life-saving but optimal application remains uncertain.

Purpose of the Study:

  • To present current evidence supporting best practices in RRT for critically ill patients with AKI.
  • To address controversies and uncertainties in RRT for AKI.

Main Methods:

  • Synthetic review of English language literature.
  • Searched MEDLINE and PubMed databases.
  • Included review of bibliographic citations.

Main Results:

  • Evidence clarifies several controversial areas in RRT for AKI.
  • Identified key areas for best practice in RRT for AKI.
  • Highlighted remaining questions for future research.

Conclusions:

  • Current evidence provides a foundation for best practices in RRT for AKI.
  • Ongoing and future investigations are needed to answer remaining questions.
  • Optimizing RRT is crucial for improving outcomes in critically ill AKI patients.