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Related Experiment Video

Updated: Jan 29, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
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Rationally designed DNA-based nanocarriers.

Qiao Jiang1, Shuai Zhao2, Jianbing Liu1

  • 1CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.

Advanced Drug Delivery Reviews
|February 16, 2019
PubMed
Summary

DNA nanocarriers offer a promising alternative to conventional nanoparticles for cancer treatment. Their unique properties enable precise tumor targeting and controlled drug release, improving therapeutic outcomes.

Keywords:
DNA nanostructuresDrug deliveryIn vivo cancer treatmentsNanocarriersSelf-assembly

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Materials Science

Background:

  • Conventional nanoparticles face limitations in cancer therapy, including poor biocompatibility and tumor targeting.
  • DNA nanocarriers present a novel platform leveraging nanotechnology and biological sciences for improved cancer treatment.

Purpose of the Study:

  • To review recent advancements in DNA-based self-assembled materials for biomedical applications in cancer diagnosis and therapy.
  • To introduce fabrication strategies and requirements for DNA nanocarriers.
  • To summarize DNA nanocarrier progress based on functionality and structural properties.

Main Methods:

  • Review of recent scientific literature on DNA-based nanocarriers for cancer treatment.
  • Analysis of DNA nanocarrier properties like size, shape, programmability, and biocompatibility.
  • Categorization of nanocarriers by functionality for tumor recognition, therapy, and drug release.

Main Results:

  • DNA nanostructures exhibit uniform size/shape, programmability, and excellent biocompatibility.
  • These features enable precise tumor targeting, customized therapies, and stimuli-responsive drug release.
  • DNA nanocarriers show potential in molecular imaging and in vitro/in vivo cancer treatment.

Conclusions:

  • DNA nanocarriers are highly attractive for cancer therapy due to their versatile and programmable nature.
  • Further research on in vivo parameters and intelligent nanomedicine design is crucial for individualized cancer therapy.
  • DNA-based materials offer significant promise for overcoming limitations of current nanomedicine approaches.