Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alterations in Respiration II01:30

Alterations in Respiration II

1.8K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.8K
The Auditory Ossicles01:11

The Auditory Ossicles

3.1K
The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two malleus (hammer) bones, two incus (anvil) bones, and two stapes (stirrups), one on each side. These bones develop during the fetal stage and are the ones to ossify first. They are fully mature at birth and do not grow afterward.
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
3.1K
Altered States of Awareness01:06

Altered States of Awareness

1.1K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.1K
Auditory Pathway01:15

Auditory Pathway

7.3K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
7.3K
Auditory Perception01:17

Auditory Perception

1.1K
The auditory system is essential for sound perception, utilizing various critical structures. When sound waves enter the outer ear, they travel through the ear canal and cause the eardrum to vibrate. These vibrations are then transmitted to the middle ear, where three tiny bones – the malleus, incus, and stapes – amplify the sound. This amplification is crucial, as it ensures that the sound vibrations are strong enough to be conveyed to the inner ear. These vibrations then reach the...
1.1K
Aging01:26

Aging

673
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
673

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computational Auditory Periphery Models: the Return of the Rodent.

ArXiv·2026
Same author

Computational auditory periphery models: The return of the rodent.

Hearing research·2026
Same author

Spectroscopic limits of diamond anvils to 520 GPa and projected bandgap closure.

Nature communications·2026
Same author

Asymmetric pulses delivered by a cochlear implant allow a reduction in evoked firing rate and in spatial activation in the guinea pig auditory cortex.

Hearing research·2024
Same author

Unveiling the presence of endocrine disrupting chemicals in northern French soils: Land cover variability and implications.

The Science of the total environment·2023
Same author

Robustness to Noise in the Auditory System: A Distributed and Predictable Property.

eNeuro·2021
Same journal

Gating effects of a Cav2.3 calcium channel variant linked to developmental and epileptic encephalopathy.

Neuroscience·2026
Same journal

Identification of polyamine metabolism-related gene signatures for prognostic and immunological stratification in glioma.

Neuroscience·2026
Same journal

Age- and sex-dependent effects of single prolonged stress on behavioral, hematological, and oxidative stress parameters in C57BL/6J mice.

Neuroscience·2026
Same journal

Accelerated long-term forgetting and relevant biomarkers for early detection in preclinical Alzheimer's disease.

Neuroscience·2026
Same journal

Deciphering key factors contributing to age-related decline in visuomotor tracking through the manipulation of target refresh rate and gaze contingency.

Neuroscience·2026
Same journal

LPI alleviates Alzheimer's disease pathology via the GPR55 receptor.

Neuroscience·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Isolation and Culture of Primary Retinal Müller Cells from Sprague-Dawley (SD) Rats
07:41

Isolation and Culture of Primary Retinal Müller Cells from Sprague-Dawley (SD) Rats

Published on: June 17, 2025

906

Age-related Changes in Auditory Cortex Without Detectable Peripheral Alterations: A Multi-level Study in

F Occelli1, F Hasselmann2, J Bourien2

  • 1Institut de NeuroScience Paris-Saclay (NeuroPSI), University Paris-Sud, 91405 Orsay cedex, France; UMR CNRS 9197, University Paris-Sud, 91405 Orsay cedex, France.

Neuroscience
|February 16, 2019
PubMed
Summary
This summary is machine-generated.

Aging impacts the central auditory system, including the brainstem and cortex, even when the peripheral cochlea shows no decline. Central aging affects sound processing and behavior, independent of peripheral changes.

Keywords:
behavioral taskcentral auditory systemcompound action potentialmulti-unit recordingssynaptic ribbons

More Related Videos

A Method of Nodose Ganglia Injection in Sprague-Dawley Rat
09:28

A Method of Nodose Ganglia Injection in Sprague-Dawley Rat

Published on: November 25, 2014

19.9K
Generation of Neurospheres from Mixed Primary Hippocampal and Cortical Neurons Isolated from E14-E16 Sprague Dawley Rat Embryo
12:22

Generation of Neurospheres from Mixed Primary Hippocampal and Cortical Neurons Isolated from E14-E16 Sprague Dawley Rat Embryo

Published on: August 31, 2019

9.5K

Related Experiment Videos

Last Updated: Jan 29, 2026

Isolation and Culture of Primary Retinal Müller Cells from Sprague-Dawley (SD) Rats
07:41

Isolation and Culture of Primary Retinal Müller Cells from Sprague-Dawley (SD) Rats

Published on: June 17, 2025

906
A Method of Nodose Ganglia Injection in Sprague-Dawley Rat
09:28

A Method of Nodose Ganglia Injection in Sprague-Dawley Rat

Published on: November 25, 2014

19.9K
Generation of Neurospheres from Mixed Primary Hippocampal and Cortical Neurons Isolated from E14-E16 Sprague Dawley Rat Embryo
12:22

Generation of Neurospheres from Mixed Primary Hippocampal and Cortical Neurons Isolated from E14-E16 Sprague Dawley Rat Embryo

Published on: August 31, 2019

9.5K

Area of Science:

  • Neuroscience
  • Auditory System Research
  • Aging Studies

Background:

  • Aging affects both peripheral (cochlea) and central (brainstem, cortex) auditory systems.
  • Understanding age-related changes in auditory processing is crucial for maintaining quality of life.

Purpose of the Study:

  • To investigate the effects of aging on the cochlea, brainstem, and cortex in female Sprague-Dawley rats.
  • To determine if central auditory system aging occurs independently of peripheral aging.

Main Methods:

  • Assessed auditory nerve thresholds, distortion product otoacoustic emissions, and inner hair cell synapses.
  • Measured brainstem response amplitudes and thresholds.
  • Analyzed primary auditory cortex neuronal responses (receptive field size, temporal reliability) and behavioral performance in aging rats.

Main Results:

  • Peripheral auditory system showed no significant aging effects between 9 and 21 months.
  • Brainstem response amplitudes decreased with age, with thresholds increasing after 15 months.
  • Cortical neurons exhibited narrower receptive fields and reduced temporal reliability at 21 months, but improved performance in noise and specific sound processing tasks.

Conclusions:

  • Central auditory system aging, particularly in the cortex, can occur independently of peripheral cochlear aging.
  • Age-related changes in the brainstem and cortex affect auditory perception and behavior.
  • These findings highlight the complex, multi-level impact of aging on the auditory system.