Related Experiment Video

Updated: Jan 29, 2026

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

16.0K

Decrease in oxidized high-density lipoprotein is associated with slowed progression of coronary artery calcification:

Takashi Miki1, Toru Miyoshi1, Kazuhiko Kotani2

  • 1Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Density and Pharmaceutical Sciences, Okayama, Japan.

Atherosclerosis
|February 16, 2019
PubMed

Insights

A decrease in oxidized high-density lipoprotein (oxHDL) levels was linked to slower progression of coronary artery calcification (CAC). This suggests oxHDL may be a target for preventing atherosclerosis.

Area of Science:

  • Cardiovascular research
  • Atherosclerosis studies
  • Lipoprotein metabolism

Background:

  • Oxidized high-density lipoprotein (oxHDL) has diminished anti-inflammatory properties compared to HDL.
  • The specific role of oxHDL in coronary artery calcification (CAC) pathogenesis is not fully understood.
  • CAC is a key indicator of subclinical atherosclerosis.

Purpose of the Study:

  • To prospectively examine the association between changes in oxHDL levels and CAC progression.
  • To evaluate oxHDL as a potential biomarker and therapeutic target in atherosclerosis.

Main Methods:

  • A substudy of 140 patients from a multicenter trial was conducted.
  • Patients received pitavastatin with or without eicosapentaenoic acid.
  • Coronary artery calcification (CAC) was measured at baseline and 1-year follow-up using computed tomography.

Main Results:

  • A significant decrease in oxHDL levels was observed post-treatment (167 to 122 U/ml, p < 0.001).
  • Annual CAC change positively correlated with changes in oxHDL (r=0.17, p=0.04), triglycerides, and hs-CRP.
  • A decrease in oxHDL was independently associated with reduced CAC progression (OR, 0.95; 95% CI, 0.90-0.99; p=0.04).

Conclusions:

  • Reduced oxHDL levels correlate with attenuated CAC progression.
  • oxHDL may serve as a potential therapeutic target for atherosclerosis prevention.
  • Further research into oxHDL's role in cardiovascular disease is warranted.
Abstract

Keywords:
AtherosclerosisComputed tomographyCoronary artery calcificationHigh-density lipoproteinOxidized lipoprotein

More Related Videos

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification10:39

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

Published on: November 28, 2016

11.8K
Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

984

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.1K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
420
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
249
Decreasing Function01:27

Decreasing Function

A decreasing function describes a relationship where the output consistently declines as the input increases. This means that for any two input values, if one is greater than the other, the corresponding output is smaller. Mathematically, a function f is decreasing on an interval I if for every x1 < x2​ in I, f (x1) > f (x2). This type of behavior is visually identified on a graph that slopes downward from left to right.The nature of a function can be analyzed by calculating...
267
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
364
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
663