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Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029

Mathilde Bonnet1, Aurélie Maisonial-Besset2, Yingying Zhu3

  • 1Université Clermont Auvergne, INSERM1071, Microbes, Intestins, Inflammation et Susceptibilité de l'hôte, 63001 Clermont-Ferrand CEDEX 1, France. mathilde.bonnet@uca.fr.

Cancers
|February 17, 2019
PubMed

Insights

Tetraspanins, like Tspan8/Co-029, are cell surface proteins targeted by antibodies. This review explores their function in tumor cells and potential use in targeted cancer immunotherapies.

Area of Science:

  • Cell Biology
  • Immunology
  • Oncology

Background:

  • Tetraspanins are integral membrane proteins found on the cell surface.
  • Their surface exposure facilitates antibody binding for functional studies.
  • Tspan8/Co-029 is a specific tetraspanin implicated in cellular processes.

Purpose of the Study:

  • To review the functions of Tspan8/Co-029 in tumor cell biology.
  • To discuss the potential of targeting Tspan8 in cancer immunotherapy.
  • To explore the use of antibodies against Tspan8 in radioimmunotherapy.

Main Methods:

  • Literature review of recent studies on Tspan8/Co-029.
  • Analysis of genetic data related to tetraspanin function.
  • Evaluation of antibody-based therapeutic strategies.

Main Results:

  • Tspan8/Co-029 plays a significant role in the biology of tumor cells.
  • Antibodies targeting Tspan8 show promise for immunotherapy.
  • Radioimmunotherapy approaches utilizing Tspan8 antibodies are under investigation.

Conclusions:

  • Understanding tetraspanin functions, particularly Tspan8, is crucial for cancer research.
  • Antibody-mediated targeting of Tspan8 offers potential therapeutic avenues.
  • Further research into Tspan8-targeted therapies could advance cancer treatment.
Keywords:
Tspan8cancerimmunotherapyradioimmunotherapytetraspanins

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