Related Experiment Video

Updated: Jan 29, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

9.9K

MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal Cancer

Yiling Situ1, Liping Chung2,3, Cheok Soon Lee4,5,6,7,8,9

  • 1School of Medicine, Western Sydney University, Penrith, NSW 2751, Australia. ysitu.dr@gmail.com.

International Journal of Molecular Sciences
|February 17, 2019
PubMed

Insights

The MRE11-RAD50-NBS1 (MRN) complex is implicated in mismatch repair-defective cancers like colorectal cancer (CRC). Research suggests MRN complex alterations may serve as biomarkers and therapeutic targets for improving CRC patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The MRE11-RAD50-NBS1 (MRN) complex is crucial for DNA repair pathways.
  • Mutations in the MRN complex are observed in mismatch repair (MMR)-defective cancers.
  • Its specific role in colorectal cancer (CRC) warrants further investigation.

Purpose of the Study:

  • To review the function of the MRN complex in cancer.
  • To explore the MRN complex's role and significance in colorectal cancer progression.
  • To assess the potential of the MRN complex as a biomarker and therapeutic target in CRC.

Main Methods:

  • Literature review of existing studies on the MRN complex.
  • Analysis of evidence linking MRN complex expression to patient survival.
  • Synthesis of current research on MRN complex function in CRC.

Main Results:

  • Evidence suggests a correlation between MRN complex expression and reduced progression-free survival in some cancers.
  • The clinical significance of the MRN complex in colorectal cancer remains debated.
  • The MRN complex is implicated in DNA damage response pathways relevant to cancer.

Conclusions:

  • The MRN complex plays a role in DNA repair and cancer progression.
  • Further research is needed to clarify the controversial clinical significance of the MRN complex in CRC.
  • The MRN complex shows potential as a biomarker and therapeutic target for improving colorectal cancer outcomes.
Keywords:
DNA damage responseMRE11-RAD50-NBS1 complexbiomarkerscolorectal cancerprognosisradiosensitivity

More Related Videos

Orthotopic Mouse Model of Colorectal Cancer08:43

Orthotopic Mouse Model of Colorectal Cancer

Published on: December 4, 2007

47.1K
Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

2.8K

Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.2K
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.4K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.1K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.1K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.0K
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.8K