Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chromosome Structure02:40

Chromosome Structure

26.3K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
26.3K
Chromosome Structure02:40

Chromosome Structure

6.2K
6.2K
Chromosome Replication02:31

Chromosome Replication

10.6K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
10.6K
Polytene Chromosomes02:04

Polytene Chromosomes

11.0K
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also...
11.0K
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

8.7K
In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
8.7K
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

2.9K
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Giant Sex Chromosomes in <i>Omophoita</i> Species (Coleoptera, Chrysomelidae): Structural and Evolutionary Relationships Revealed by Zoo-FISH and Comparative Genomic Hybridization (CGH).

Insects·2023
Same author

Case Report: Identification of likely recurrent <i>CEP290</i> mutation in a child with Joubert syndrome and cerebello-retinal-renal features.

F1000Research·2023
Same author

Chromosomes of Asian Cyprinid Fishes: Genomic Differences in Conserved Karyotypes of 'Poropuntiinae' (Teleostei, Cyprinidae).

Animals : an open access journal from MDPI·2023
Same author

Functional Characterization of Transgenic Mice Overexpressing Human 15-Lipoxygenase-1 (ALOX15) under the Control of the aP2 Promoter.

International journal of molecular sciences·2023
Same author

Mucopolysaccharidosis type III (subtype IIIB) diagnosis as a spectrum disorder: A case report from Kosovo.

Folia medica·2023
Same author

Joubert syndrome: Molecular basis and treatment.

Journal of mother and child·2023

Related Experiment Video

Updated: Jan 29, 2026

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
06:25

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

Published on: February 6, 2012

19.4K

From Human Cytogenetics to Human Chromosomics.

Thomas Liehr1

  • 1Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Am Klinikum 1, D-07747 Jena, Germany. Thomas.Liehr@med.uni-jena.de.

International Journal of Molecular Sciences
|February 17, 2019
PubMed
Summary
This summary is machine-generated.

Chromosomics, the study of chromosome 3D structure and gene interactions, was predicted to impact human genetics. Despite progress, a shift in research focus has stalled its advancement, necessitating a reevaluation of its role.

Keywords:
chromosomeschromosomicscytogeneticsepigeneticsinterphase-architecture

More Related Videos

Chromosomal Spread Preparation of Human Embryonic Stem Cells for Karyotyping
10:42

Chromosomal Spread Preparation of Human Embryonic Stem Cells for Karyotyping

Published on: September 4, 2009

49.5K
Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
12:32

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Published on: September 7, 2021

2.6K

Related Experiment Videos

Last Updated: Jan 29, 2026

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
06:25

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

Published on: February 6, 2012

19.4K
Chromosomal Spread Preparation of Human Embryonic Stem Cells for Karyotyping
10:42

Chromosomal Spread Preparation of Human Embryonic Stem Cells for Karyotyping

Published on: September 4, 2009

49.5K
Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
12:32

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Published on: September 7, 2021

2.6K

Area of Science:

  • Genetics
  • Cell Biology
  • Genomics

Background:

  • Introduced in 2005, chromosomics explores the 3D structure and plasticity of genes within interphase nuclei.
  • This review honors Prof. Uwe Claussen, a pioneer in the field of chromosomics.

Purpose of the Study:

  • To discuss the concept of chromosomics and its implications for understanding human chromosome structure.
  • To review recent progress in chromosomics and its potential impact on human genetics.

Main Methods:

  • Review of existing literature on chromosomics.
  • Analysis of chromosome-chromosome interactions and their link to disease.
  • Discussion of research trends in human genetics.

Main Results:

  • Chromosomics investigates chromosome positioning, gene interactions, and chromatin modification effects.
  • Detected chromosome-chromosome interactions are linked to cellular malfunction and disease.
  • Current human genetics research prioritizes high-throughput genomic approaches over chromosomics.

Conclusions:

  • Prof. Claussen's 2005 predictions regarding chromosomics' impact have been validated.
  • While progress has been made, a reconsideration of chromosomics' role in human genetics is crucial.
  • Re-emphasizing the importance of single-cell studies and chromosomal insights is necessary for future advancements.