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Conservation of Protein Domains Over Different Proteins

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Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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Related Experiment Video

Updated: Jan 29, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Cilia Distal Domain: Diversity in Evolutionarily Conserved Structures.

Helena Soares^1,2, Bruno Carmona^3,4, Sofia Nolasco^5,6

¹Center for Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, 1749-016 Lisbon, Portugal. mhsoares@fc.ul.pt.

|February 17, 2019

Summary

This summary is machine-generated.

Eukaryotic cilia exhibit diverse structures, particularly at their tips, influencing function and disease. Microtubule caps stabilize cilia but their roles require further investigation.

Keywords:

cilia cilia distal domain cilia structural diversity microtubule-capping structures

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Artificial Intelligence Approaches to Assessing Primary Cilia

Artificial Intelligence Approaches to Assessing Primary Cilia

Published on: May 1, 2021

Area of Science:

Cell Biology
Structural Biology

Background:

Eukaryotic cilia are essential microtubule-based organelles involved in cell sensing and movement.
Cilia display significant structural variations across species and even within organisms, impacting their function.
Dysfunctional cilia cause human diseases known as ciliopathies, highlighting the need to understand their structure-function relationships.

Purpose of the Study:

To review the structural diversity of eukaryotic cilia, focusing on the distal ciliary domain.
To explore the role of microtubule-capping structures (caps) in cilia.
To discuss how ciliary structural diversity, especially at the tip, affects cilia function and disease.

Main Methods:

Literature review of current knowledge on cilia structure and function.
Focus on the distal ciliary domain, including axoneme endings and microtubule caps.
Analysis of the relationship between ciliary structure, function, and ciliopathies.

Main Results:

Cilia exhibit diverse ultra-structures, particularly at the distal tip, influencing assembly, transport, and signaling.
Microtubule caps are present in some cilia types and are proposed to regulate axoneme length and stability.
The precise roles of these caps and their contribution to ciliary diversity remain poorly understood.

Conclusions:

Ciliary structural diversity, especially at the distal end and involving microtubule caps, is critical for diverse cellular functions.
Further research into ciliary tip architecture and the function of microtubule caps is essential for understanding ciliopathies.