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Molecules that make axons grow.

A D Lander1

  • 1Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.

Molecular Neurobiology
|January 1, 1987
PubMed
Summary
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Researchers identified molecules like nerve growth factor that promote neurite growth. These substances may control axon behavior and guidance in living organisms, offering insights into neural development.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Neurite outgrowth in tissue culture is a key model for studying axon behavior.
  • Several molecules are known to promote neurite outgrowth, including growth factors and extracellular matrix proteins.

Purpose of the Study:

  • To identify substances controlling axon behavior in vivo.
  • To compare the cellular effects of known neurite-promoting molecules.
  • To discuss evidence for in vivo axon guidance and identify common mechanisms of action.

Main Methods:

  • Review of existing literature on neurite growth.
  • Comparison of cellular effects of identified molecules.
  • Discussion of in vivo evidence for axon guidance.

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Main Results:

  • Nerve growth factor, laminin, and fibronectin promote neurite outgrowth.
  • A glia-derived protease inhibitor also influences neurite behavior.
  • Evidence suggests these molecules play roles in axon growth and guidance in vivo.

Conclusions:

  • Identified molecules offer potential for controlling axon behavior in vivo.
  • Understanding common mechanisms of action is crucial for neural development research.
  • Further investigation into less-characterized molecules is warranted.