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Updated: Jan 29, 2026

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Three-dimensional Optical-resolution Photoacoustic Microscopy
Published on: May 3, 2011
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Micron resolution, high-fidelity three-dimensional vascular optical imaging phantoms
Callum D Little1,2, Radhika K Poduval3,4, Richard Caulfield1,4,5
1Wellcome Trust-EPSRC Centre for Interventional and Surgical Sciences, London, United Kingdom.
Journal of Biomedical Optics
|February 17, 2019
Summary
Researchers developed a novel method for creating detailed 3D optical imaging phantoms. This technique uses two-photon polymerization (2PP) and microinjection to accurately mimic complex biological tissues and pathologies for enhanced system characterization.
Area of Science:
- Biomedical Engineering
- Optical Imaging
- Materials Science
Background:
- Three-dimensional (3-D) optical imaging techniques are crucial for visualizing biological tissues at microscopic and mesoscale levels.
- Existing phantom models lack the resolution and complexity to adequately characterize advanced imaging systems and train clinicians.
- Replicating intricate 3-D geometries with both structural and molecular contrast at sub-20 μm resolution remains a significant challenge.
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