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Updated: Jan 29, 2026
Measuring Left Ventricular Pressure in Late Embryonic and Neonatal Mice
Published on: February 23, 2012
The Relationship between blood pressure parameters and left ventricular output in neonates
Ashraf Kharrat1, Daniel Ibarra Rios2, Dany E Weisz1,3
1Department of Paediatrics, University of Toronto, Toronto, ON, Canada.
Objective:
To evaluate the relationship between systolic (SBP), diastolic (DBP), mean (MBP) blood pressures and pulse pressure (PP), and left ventricular output (LVO), a surrogate of systemic blood flow.
Study Design:
This retrospective study included neonates who underwent targeted neonatal echocardiography (TNE) in 3-tertiary NICUs over 2 years. Associations between LVO and BP components were investigated. Analysis was adjusted for relevant covariates.
Result:
1060 studies from 485 neonates were included, with a mean GA of 28.4 ± 4.6 weeks and birth weight of 1234 ± 840 grams. LVO was associated positively with SBP and PP, and negatively with GA. PP demonstrated the highest predictive value for identifying infants with LVO < 150 ml/kg/min (area under the curve 0.75 [95% CI 0.68, 0.82]). MBP and DBP demonstrated no correlation with LVO.
Conclusion:
BP parameters correlate poorly with LVO, irrespective of GA and underlying etiology. Narrow PP may be more reflective of low LVO than low SBP.
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