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Genetics and epigenetics in primary Sjögren's syndrome

Juliana Imgenberg-Kreuz1, Astrid Rasmussen1, Kathy Sivils1

  • 1Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden2Arthritis and Clinical Immunology Research Program, Division of Genomics and Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Rheumatology (Oxford, England)
|February 17, 2019
PubMed
Summary

Primary Sjögren's syndrome (pSS) is a complex autoimmune disease influenced by genetics and epigenetics. Research highlights HLA, IRF5, and STAT4 genes, alongside epigenetic factors like DNA methylation, in pSS development.

Keywords:
DNA methylationGWASHLAIRF5STAT4epigeneticsgeneticshistone modificationnon-coding RNAprimary Sjögren’s syndrome

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