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Generation and Analysis of Viral Vector-Mediated Rodent Models for Parkinson's Disease
Akua A Karikari1, James B Koprich2, Chi Wang Ip1
1Department of Neurology, University Hospital of Würzburg, Würzburg, Germany.
Methods in Molecular Biology (Clifton, N.J.)
|February 17, 2019
Abstract:
The use of viral vector-mediated α-synuclein-overexpressing rodent models for Parkinson's disease has become increasingly accepted to study associated pathology and to use as a platform for therapeutic efficacy testing. We here describe methods to generate such models and how to analyze them by behavioral assessments, histological investigations, and examination of nigrostriatal dopaminergic function.