Neuroprotective effects of agmatine in antineoplastic drugs induced neurotoxicity: In vitro study
Damla Binnetoglu1, Ahmet Hacimuftuoglu2, Feyza Aricioglu3
1Department of Medical Pharmacology, Faculty of Medicine, Kafkas University, Kars, Turkey.
Aims:
The effects of agmatine, an endogenous substance known to have a neuroprotective effect against neurotoxicity has been investigated.
Material And Methods:
The primary neuron culture obtained from neonatal rats was exposed to toxicity with paclitaxel and cisplatin and the effect of agmatine on both acute (1 h) and chronic (24 h) exposure was demonstrated by biochemical and molecular analyses. It was demonstrated that the effect of agmatine before and after agmatine was induced by neurotoxicity before agmatine and the effect of agmatine on the formed and occuring toxicities. In addition to the results of cell viability assay, total oxidant capacity and total antioxidant capacity, we have found the opportunity to elaborate on our molecular mechanisms by elaborating our findings with apoptotic and inflammation markers such as caspase 3, kaspase 9 and TNF alpha.
Key Findings:
The results of our study revealed the effect profile of a protective molecule against pathological neural deaths due to neurodegeneration not only in neurotoxicity due to anticancer drugs.
Significance:
In this context, we tried to reverse neurotoxicity due to anticancer drugs by using agmatine the duration (1 and 24 h) and dosage (10-5 M and 10-6 M) determined.
Related Concept Videos
Methods for Studying Drug Absorption: In vitro
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
Combined Effects of Drugs: Antagonism
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
Antipsychotic Drugs: Therapeutic Uses and Side Effects
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Combined Effects of Drugs: Synergism
Such synergistic combinations...
In Vitro Drug Dissolution: Alternative Methods
Drug Product Performance: In Vitro–In Vivo Correlation


