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Updated: Jan 29, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
Ultrasound-enhanced scintillation proximity assay for rapid diagnostics
So-Young Lee1, Jae-Cheong Lim1, Eun-Ha Cho1
1Radioisotope Research Division, Korea Atomic Energy Research Institute (KAERI), Daejeon, 305-353, Republic of Korea.
Abstract:
Scintillation proximity assay (SPA) is a type of radioimmunoassay (RIA). We apply ultrasound enhancement to the general SPA. All assay procedures, including the antibody coating and radiolabeled antigen binding are achieved by simply mixing then standing for 5 min in an ultrasound chamber. No additional incubation time is required. To further demonstrate the capability of the UE-SPA, a quantitative measurement of CD55 in various grades of colon tumors was assessed on human tissue slides. The results showed a significant correlation between CD55 expression and tumorigenesis. In conclusion, we confirmed that UE-SPA is a reliable, rapid and alternative to RIA.
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