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Structure Solution of the Fluorescent Protein Cerulean Using MeshAndCollect

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Published on: March 19, 2019

Periplasmic solute-binding proteins: Structure classification and chitooligosaccharide recognition.

Tamo Fukamizo¹, Yoshihito Kitaoku¹, Wipa Suginta²

¹Biochemistry and Electrochemistry Research Unit and School of Chemistry, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.

International Journal of Biological Macromolecules

|February 17, 2019

Summary

This summary is machine-generated.

This study reviews chitooligosaccharide-binding proteins (CBPs) in marine bacteria. Their structure and substrate specificity offer potential for engineering nutrient uptake in these organisms.

Keywords:

Chitin metabolism Chitoligosaccharide, classification Crystal structures Marine bacteria Periplasmic solute-binding proteins Sugar recognition

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Area of Science:

Microbiology
Structural Biology

Background:

Periplasmic solute-binding proteins (SBPs) are crucial for nutrient transport across bacterial membranes.
SBPs are classified into clusters (A-G) and subclusters (e.g., IV) based on structural and functional characteristics.

Purpose of the Study:

To review the classification, structure, and substrate specificity of chitooligosaccharide-binding proteins (CBPs).
To explore the potential for engineering CBP substrate specificity in marine bacteria.

Main Methods:

Classification of SBPs based on crystal structures.
Analysis of reported CBP structures (VhCBP, VcCBP) from marine Vibrio species.
Comparison of Vibrio CBPs with homologous proteins, such as the cellobiose-binding protein from Thermotoga maritima.

Main Results:

Chitooligosaccharide-binding proteins (CBPs) belong to cluster C/subcluster IV of SBPs.
Vibrio CBPs specifically recognize linear β-1,4- or β-1,3-linked oligosaccharides.
Structural similarity exists between Vibrio CBPs and cellobiose-binding proteins from T. maritima.

Conclusions:

The structural insights into Vibrio CBPs provide a basis for protein engineering.
Engineering CBP specificity could enable control over chitinous and cellulosic nutrient uptake in marine bacteria.