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Long non-coding RNA FGF13-AS1 inhibits glycolysis and stemness properties of breast cancer cells through

Fei Ma1, Xu Liu1, Shibo Zhou2

  • 1Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.

Cancer Letters
|February 17, 2019
PubMed

Insights

Long non-coding RNA FGF13-AS1 acts as a tumor suppressor in breast cancer by inhibiting cell proliferation, migration, and invasion. Its downregulation is linked to poor prognosis, suggesting a new therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are critical in breast cancer development.
  • LncRNA FGF13-AS1 is downregulated in breast cancer and associated with poor prognosis.

Purpose of the Study:

  • To investigate the role of FGF13-AS1 in breast cancer.
  • To elucidate the underlying molecular mechanisms of FGF13-AS1 action.

Main Methods:

  • Analysis of FGF13-AS1 expression in breast cancer tissues.
  • Functional assays to assess the impact of FGF13-AS1 on cell proliferation, migration, and invasion.
  • Mechanistic studies involving RNA-binding proteins (IGF2BPs) and c-Myc mRNA stability.

Main Results:

  • FGF13-AS1 expression is decreased in breast cancer tissues.
  • FGF13-AS1 suppresses breast cancer cell proliferation, migration, and invasion by impairing glycolysis and stemness.
  • FGF13-AS1 reduces c-Myc mRNA half-life by interacting with IGF2BPs, and c-Myc transcriptionally inhibits FGF13-AS1, forming a feedback loop.

Conclusions:

  • FGF13-AS1 acts as a tumor suppressor in breast cancer.
  • The FGF13-AS1/IGF2BPs/Myc feedback loop represents a potential therapeutic target for breast cancer treatment.
Keywords:
Lnc FGF13-AS1MetabolismStemnessc-Myc

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