Related Experiment Video
Updated: Jan 29, 2026
04:34
Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
1.6K
Direct Aspiration versus Stent Retriever Thrombectomy for Acute Stroke: A Systematic Review and Meta-Analysis in 9127
Christopher T Primiani1, Angel Chinea Vicente1, Michael T Brannick2
1Department of Neurosurgery, University of South Florida, Tampa, Florida.
Summary
Direct aspiration thrombectomy is a safe and effective alternative for acute ischemic stroke, showing comparable clinical outcomes to stent retrievers. This approach, with or without a stent retriever, offers similar benefits in stroke management.
Area of Science:
- Neurology
- Interventional Cardiology
- Neurosurgery
Background:
- Emergent large vessel occlusion (ELVO) stroke management relies on thrombectomy.
- Direct aspiration and primary stent retriever thrombectomy are common but lack direct comparative data on risks and benefits.
Purpose of the Study:
- To systematically review and meta-analyze radiographic and clinical outcomes of primary stent retriever versus direct aspiration thrombectomy for acute ischemic stroke.
Main Methods:
- Systematic review and meta-analysis of studies from PubMed (September 2012 - December 2017).
- Included patients with acute ischemic stroke undergoing thrombectomy.
Main Results:
- Analyzed 64 studies (6875 patients) for stent retrievers and 25 studies (2252 patients) for aspiration.
- Aspiration achieved higher successful recanalization rates (89% vs. 80%, P < .0001).
- No significant differences in good clinical outcomes (mRS 0-2), symptomatic intracerebral hemorrhage, or 3-month mortality.
Conclusions:
- Both aspiration-first and primary stent retriever thrombectomy are equally effective for good clinical outcomes in acute ischemic stroke.
- Direct aspiration, with or without a stent retriever, is a safe and effective alternative to primary stent retriever thrombectomy.
Related Concept Videos
01:09Directing Effect of Substituents: meta-Directing Groups
5.9K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
5.9K
01:13meta-Directing Deactivators: –NO2, –CN, –CHO, –CO2R, –COR, –CO2H
6.7K
All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
6.7K
01:12Retrieval
438
Retrieval is the process of getting information out of memory storage and back into conscious awareness. This ability is essential for daily tasks like brushing hair and teeth, driving to work, and performing job duties. Retrieval occurs in three ways: recall, recognition, and relearning.
Recall involves accessing information without cues, such as during an essay test, where individuals must retrieve facts and concepts from memory unaided. Another example is remembering the name of a colleague...
Recall involves accessing information without cues, such as during an essay test, where individuals must retrieve facts and concepts from memory unaided. Another example is remembering the name of a colleague...
438
01:10Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
01:13Review and Preview
11.2K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K
01:45ER Retrieval Pathway
4.8K
In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
4.8K