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Updated: Jan 29, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
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Hemilingual Angioedema after Thrombolysis in a Patient on an Angiotensin II Receptor Blocker

Jose Danilo Bengzon Diestro1, Lady Scarlette Pacsi Sedano1, Nikolai Gil Diwa Reyes1

  • 1Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|February 18, 2019
PubMed

Orolingual angioedema (OLAE) is a rare adverse effect of alteplase. Previous studies have associated the occurrence of OLAE with thrombolysed patients maintained on angiotensin converting enzyme inhibitors. We report a case of a 60-year-old male presenting with hyperacute ischemic stroke developing hemilingual edema after thrombolysis. He was previously maintained on an angiotensin II receptor blocker (ARB), losartan. The swelling resolved over 2 days with immediate administration of intravenous steroids and antihistamine drugs. Our case is the third documented case of OLAE occurring in a thrombolysed patient concurrently taking an ARB. The presence of hemilingual edema in a post-thrombolysis patient maintained on losartan suggests a possible association between OLAE and ARBs.

Keywords:
Alteplaseacute strokeorolingual angioedemathrombolysistongue swelling

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