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Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
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Prevalence and Clinical Patterns of Ocular Complications Associated With Anti-PD-1/PD-L1 Anticancer Immunotherapy

Karen Bitton1, Jean-Marie Michot2, Emmanuel Barreau3

  • 1Service d'Ophtalmologie, DHU Vision & Handicaps, Centre de référence pour les maladies rares en ophtalmologie (OPHTARA), Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris, Le Kremlin-Bicêtre, France; Université Paris-Sud, Le Kremlin-Bicêtre, France.

American Journal of Ophthalmology
|February 18, 2019
PubMed
Abstract

Insights

Immune checkpoint inhibitors (ICI) can cause rare but serious eye problems. Early ophthalmologic evaluation is crucial for patients experiencing vision changes during ICI therapy to prevent vision loss.

Area of Science:

  • Oncology
  • Ophthalmology
  • Immunology

Background:

  • Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1) or its ligand PD-L1 are standard treatments for metastatic cancers.
  • Patients undergoing ICI therapy are at risk of developing immune-related adverse events (irAEs).

Purpose of the Study:

  • To determine the prevalence of moderate-to-severe ocular irAEs in patients treated with anti-PD-(L)1 therapy.
  • To describe the clinical characteristics and outcomes of these ocular irAEs.

Main Methods:

  • A prospective case series design was employed, combining data from a single-center prospective cohort and a national pharmacovigilance registry.
  • Patients with moderate-to-severe ocular irAEs following anti-PD-(L)1 treatment underwent comprehensive ophthalmologic assessments.
  • Data were collected between June 2014 and March 2018.

Main Results:

  • The prevalence of moderate-to-severe ocular irAEs was 0.4% in the prospective cohort (3 out of 745 patients).
  • Eight patients in total presented with various ocular conditions, including intraocular inflammation, ocular surface disease, and orbital myopathy.
  • Ocular irAEs necessitated permanent discontinuation of anti-PD-(L)1 treatment in 4 patients, though 7 out of 8 patients responded to corticosteroid treatment.

Conclusions:

  • Anti-PD-(L)1-associated ocular complications, while uncommon, can be sight-threatening and may lead to treatment cessation.
  • Prompt ophthalmologic consultation is essential for patients on ICI therapy who report eye-related symptoms.

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