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Updated: Jan 29, 2026

Light/dark Transition Test for Mice
Published on: November 13, 2006
The dark side of the (half) moon
Francesco Pellegrini1, Altin Stafa2, Daniela Bonsanto1
1Department of Ophthalmology, AULSS2 Marca Trevigiana, Conegliano, Treviso, Italy.
Abstract:
A 71-year-old man was referred to neuro-ophthalmology for evaluation of reading problems associated with pituitary adenoma. Perimetry showed a right temporal crescent syndrome ("half moon" syndrome) suggesting left occipital disease. Cranial magnetic resonance imaging, electroencephalogram, and cerebrospinal fluid examination (14-3-3 protein) were consistent with a diagnosis of Creutzfeldt-Jakob disease. His neurologic condition rapidly deteriorated with memory problems, myoclonus, and apathy followed by death, 4 months later. This case shows how visual problems may be the first manifestation of this rare prion disease (Heidenhain variant of Creutzfeldt-Jakob disease).
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