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Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
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Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

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Delayed resolution of retinopathy of prematurity

Mariam Ahmad1, Jennifer Patnaik1, Tamara Thevarajah1

  • 1Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
|February 18, 2019
PubMed

Insights

Infants with severe retinopathy of prematurity (ROP) or complex neonatal issues face delayed ROP resolution. Severe ROP did not progress to type 1 after 50 weeks postmenstrual age, aligning with guidelines.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Perinatal Medicine

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Timely resolution of ROP is crucial for optimal visual outcomes.
  • Identifying risk factors for delayed ROP resolution aids in targeted management.

Purpose of the Study:

  • To compare infants with ROP resolving before 50 weeks postmenstrual age (PMA) versus those resolving after 50 weeks PMA.
  • To identify risk factors associated with delayed ROP resolution.
  • To evaluate the development of severe ROP after 50 weeks PMA.

Main Methods:

  • Retrospective review of medical records of 996 infants screened for ROP.
  • Definition of delayed ROP resolution as immature retinal vasculature at ≥50 weeks PMA.
  • Comparison of birth characteristics, neonatal complications, and ROP features between infants with and without delayed resolution.

Main Results:

  • 13.6% of infants experienced delayed ROP resolution.
  • Increased ROP severity (stage, zone, plus/pre-plus disease) and type 2 ROP were linked to delayed resolution.
  • Delayed resolution was associated with prematurity (<28 weeks GA), low birth weight, sepsis, necrotizing enterocolitis, intraventricular hemorrhage, and bronchopulmonary dysplasia.

Conclusions:

  • Delayed ROP resolution is more common in infants with severe ROP or complicated neonatal courses.
  • No delayed resolution cases progressed to type 1 ROP after 50 weeks PMA, supporting current guidelines.
  • These findings aid in risk stratification and management of ROP in premature infants.
Abstract

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