Related Experiment Video

Updated: Jan 29, 2026

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.5K

Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis

D Bellavia1, A De Luca1, V Carina1

  • 1IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Bone
|February 18, 2019
PubMed

Insights

MicroRNAs (miRNAs) regulate bone cells and are implicated in osteoporosis. This review details miRNAs with validated targets in bone homeostasis and their role in osteoporosis progression and treatment.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression.
  • miRNAs play crucial roles in bone cell proliferation, differentiation, and activity.
  • Dysregulation of miRNAs is linked to bone pathologies, including osteoporosis.

Purpose of the Study:

  • To provide a comprehensive overview of miRNAs with experimentally validated targets in bone homeostasis.
  • To highlight the role of specific miRNAs in the development of osteoporosis.
  • To analyze miRNAs investigated in clinical trials for osteoporosis.

Main Methods:

  • Literature review of studies on miRNAs in bone biology.
  • Identification of miRNAs with experimentally validated targets.
  • Analysis of clinical trial data concerning miRNAs and osteoporosis.

Main Results:

  • Numerous miRNAs have been identified as key regulators of bone homeostasis.
  • miRNA deregulation is a significant factor in osteoporosis pathogenesis.
  • Several miRNAs are currently being explored in clinical trials for osteoporosis treatment.

Conclusions:

  • miRNAs are critical regulators of bone health and disease.
  • Targeting specific miRNAs holds therapeutic potential for osteoporosis.
  • Further research into miRNA mechanisms and clinical applications is warranted.
Keywords:
OsteoblastOsteoclastOsteogenesisOsteoporosismiRNA

More Related Videos

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

1.5K
A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation09:37

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

Published on: March 15, 2018

14.4K

Related Concept Videos

Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.4K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.7K
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.3K
Health Literacy01:21

Health Literacy

Health literacy is an individual's or a community's capacity to comprehend, receive, read, and use relevant healthcare information and services. The World Health Organization (WHO, 2018) defines health literacy as the cognitive and social skills that determine the ability of individuals to gain access to, understand, and use information in ways that promote and maintain good health. As a result, the WHO helps individuals manage long-term health concerns, participate in preventative...
5.3K
Purpose of Health Records I01:11

Purpose of Health Records I

The vital purpose of health records is to provide a complete and accurate account of a patient's medical history, including communication, diagnostic and therapeutic orders, care planning, research, and quality review.
Here's a breakdown of how health records serve these purposes:
1.8K