Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Antigen presentation, antigen-presenting cells and antigen processing.

¹Histopathology Department, Bland-Sutton Institute, University College and Middlesex School of Medicine, London, UK.

Current Opinion in Immunology

|December 1, 1988

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Immunosuppression as a physiological homeostatic mechanism.

Immunology today·2014

Same author

Conventional protein kinase C plays a critical role in negative regulation of CD98-induced homotypic aggregation.

Tissue antigens·2009

Same author

Autocrine type I interferon amplifies dendritic cell responses to lipopolysaccharide via the nuclear factor-kappaB/p38 pathways.

Scandinavian journal of immunology·2006

Same author

Autologous apoptotic T cells interact with dendritic cells, but do not affect their surface phenotype or their ability to induce recall immune responses.

Clinical and experimental immunology·2003

Same author

Regulation of primary HIV-1 isolate replication in dendritic cells.

Clinical and experimental immunology·2002

Same author

The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation.

Blood·2001

Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026

Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026

Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026

Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026

Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026

Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026

See all related articles

Advances in antigen presentation reveal key rules for major histocompatibility complex (MHC) association with antigens. Future research will explore T cell receptor requirements and MHC binding models in autoimmunity.

Area of Science:

Immunology
Molecular Biology
Cell Biology

Background:

Understanding how antigens associate with MHC on presenting cells is crucial for immune responses.
Existing knowledge confirms basic rules governing antigen-MHC association, including antigen nature and configuration.

Purpose of the Study:

To summarize recent advances in antigen presentation research.
To highlight new questions and future research directions in the field.

Main Methods:

Review of current literature on antigen-MHC complex formation.
Analysis of established and emerging principles in antigen processing and presentation.

Main Results:

Confirmation of basic rules for antigen-MHC association, emphasizing antigen nature and configuration.

Related Experiment Videos

Improved understanding of optimal antigen processing endpoints, despite ill-defined pathways.

Proposed rational explanation for alloreactivity dominance.

Conclusions:

Significant progress has been made in understanding antigen-MHC association.
Future studies will address T cell receptor specificity, MHC binding models, and the role of antigen presentation in autoimmunity.