Ultrasound Hyperthermia Technology for Radiosensitization.
Lifei Zhu1, Michael B Altman2, Andrei Laszlo2
1Department of Biomedical Engineering, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Ultrasound in Medicine & Biology
|February 19, 2019
Summary
Hyperthermia therapy (HT) enhances radiation therapy (RT) effectiveness. This review covers ultrasound-based HT technologies, including magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU), for improved cancer treatment outcomes.
Area of Science:
- Oncology
- Medical Physics
- Biomedical Engineering
Background:
- Hyperthermia therapy (HT) involves raising tissue temperature to 40-45°C for up to 60 minutes.
- HT is a potent sensitizer for radiation therapy (RT), enhancing treatment efficacy.
- Ultrasound-mediated HT has been clinically utilized for radiosensitization since the 1960s.
Purpose of the Study:
- To provide a comprehensive review of existing hyperthermia therapy technology.
- To summarize available ultrasound-based hyperthermia devices.
- To evaluate clinical studies combining ultrasound HT with RT and discuss future directions.
Main Methods:
- Review of existing literature on hyperthermia therapy and ultrasound technology.
- Summary of currently available ultrasound HT devices, including magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU).
- Evaluation of clinical trials and studies investigating the combination of ultrasound HT and RT.
Main Results:
- Magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) has been adapted for HT and is emerging in clinical trials for radiosensitization.
- Ultrasound-mediated HT shows promise as an effective radiosensitizer.
- Emerging clinical data suggests potential benefits of combining ultrasound HT with RT.
Conclusions:
- There is a growing need to review and understand ultrasound HT technology, particularly MRgHIFU, for radiosensitization.
- Further research and clinical trials are necessary to optimize ultrasound HT protocols and assess long-term outcomes.
- Ultrasound-mediated hyperthermia therapy represents a significant advancement in improving radiation therapy efficacy for cancer treatment.
Keywords:
CancerHyperthermiaMagnetic resonance thermometryMagnetic resonance-guided high-intensity focused ultrasoundRadiosensitizationRadiotherapyUltrasoundMore Related Videos
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