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Related Experiment Video

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Polymeric Microneedle Array Fabrication by Photolithography
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A tearable dissolving microneedle system for shortening application time.

Won-Jun Lee1, Mee-Ree Han2, Ji-Seok Kim1

  • 1a Department of BioNano Technology and Gachon BioNano Research Institute , Gachon University , Seongnam-si , South Korea.

Expert Opinion on Drug Delivery
|February 19, 2019
PubMed
Summary

A novel tearable dissolving microneedle (TD-MN) system was developed for rapid drug delivery. This system ensures immediate administration and precise dosing, enhancing patient convenience.

Keywords:
Tearable dissolving microneedlesconventional manufacturing processmicro-pillarsrapid separationshortened application time

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Area of Science:

  • Biomaterials Science
  • Dermal Drug Delivery
  • Nanotechnology

Background:

  • Conventional microneedle systems can be time-consuming for drug administration.
  • Dissolving microneedles offer a promising alternative for transdermal drug delivery.
  • There is a need for systems that ensure rapid and controlled drug release from microneedles.

Purpose of the Study:

  • To develop and evaluate a tearable dissolving microneedle (TD-MN) system for accelerated drug administration.
  • To investigate the mechanical properties and drug delivery capabilities of the TD-MN system.
  • To assess the potential of TD-MN systems for improved patient convenience and accurate dosing.

Main Methods:

  • Fabrication of a TD-MN system comprising tearable microneedles and micro-pillars.
  • Characterization of the microneedle tip separation mechanism using varying tearable region thicknesses.
  • In vitro assessment of microneedle tip separation and drug diffusion in porcine skin models using trypan blue and calcein.

Main Results:

  • The TD-MN system's tearable region thickness and tip depth were controlled by molding solution parameters.
  • Separation force increased with increasing thickness of the tearable region.
  • Successful separation of nine microneedle tips was achieved, demonstrating system functionality.

Conclusions:

  • The TD-MN system facilitates immediate drug administration into the skin.
  • This technology enhances patient convenience and ensures accurate drug dosage delivery.
  • TD-MN systems represent a significant advancement in transdermal drug delivery technology.