Related Experiment Video
Updated: Jan 29, 2026
09:19
Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice
Published on: February 2, 2019
10.5K
Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice
Kenneth Ladd Seldeen1, Yonas Z Redae1, Ramkumar Thiyagarajan1
1Division of Geriatrics and Palliative Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo and Research Service, Veterans Affairs Western New York Healthcare System.
Journal of Visualized Experiments : Jove
|February 19, 2019
Summary
Short session high-intensity interval training (HIIT) offers a therapeutic approach to combat frailty. This study presents a novel, individually tailored 10-minute HIIT protocol for aged mice, demonstrating improved physical performance in both sexes.
Area of Science:
- Gerontology
- Exercise Physiology
- Animal Models
Background:
- Frailty is a growing concern in aging populations.
- High-intensity interval training (HIIT) shows therapeutic potential for frailty.
- A gap exists in animal models for short-duration HIIT protocols.
Purpose of the Study:
- To describe a methodology for a short-session, individually tailored HIIT protocol for aged mice.
- To assess the impact of this protocol on treadmill performance in aged female mice.
- To provide a model for studying HIIT interventions in aging animal models.
Main Methods:
- Development of a 10-minute, 3-day/week HIIT protocol using an inclined treadmill for aged mice.
- Individualized tailoring of exercise intensity based on baseline anaerobic assessment.
- Progressive increases in intensity over time and modular interval design.
Main Results:
- The protocol successfully enhanced treadmill performance in aged female mice.
- This builds upon previous findings of enhanced performance in aged male mice.
- The methodology allows for precise intensity adjustments based on individual mouse response.
Conclusions:
- The described HIIT protocol is effective in improving physical performance in aged mice of both sexes.
- This individually tailored, short-session protocol is time-efficient and adaptable.
- It provides a valuable tool for investigating HIIT's anti-frailty effects in animal models.
Related Concept Videos
01:03Prediction Intervals
3.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
3.4K
01:18Actin Treadmilling
9.7K
Actin filaments undergo polymerization and depolymerization from either end. The polymerization and depolymerization rates depend on the cytosolic concentration of free G-actins. The polymerization rate is generally higher at the plus or barbed end, while the depolymerization rate is higher at the minus or pointed end. At a steady state, critical concentration describes the concentration of free G-actin monomers at which the polymerization rate at the plus end is equal to that of the...
9.7K
01:21Confidence Intervals
10.6K
An unbiased point estimate is often insufficient to predict a population estimate, such as population mean or population proportion. In this scenario, a confidence interval is used. A confidence interval is an estimate similar to a sample proportion. However, unlike the point estimate which is a single value, the confidence interval contains a range of values. These values have lower and upper limits, known as confidence limits, and can be designated as L1 and L2, respectively.
A...
A...
10.6K
01:29Improper Integrals: Infinite Intervals
96
An integral is classified as improper due to an infinite interval when at least one of its limits of integration extends to positive or negative infinity. In such cases, the region under the curve is unbounded, and standard techniques for evaluating definite integrals are not directly applicable. Instead, the improper integral is defined through a limiting process that allows one to determine whether the accumulated area remains finite despite the infinite domain.Application to Exponential...
96
00:58Sound Intensity
4.8K
The loudness of a sound source is related to how energetically the source is vibrating, consequently making the molecules of the propagation medium vibrate. To measure the loudness of a source, the physical quantity of interest is the intensity. This is defined as the energy emitted per unit of time per unit of area perpendicular to the sound wave's propagation direction. Since the total energy is greater if the source vibrates for a longer duration and over a larger area, dividing the...
4.8K
01:26Aging
673
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
673