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Orthotopic Mouse Model of Colorectal Cancer
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miR-124, a potential therapeutic target in colorectal cancer

Zhen Qin1,2, Xia Liu1,2

  • 1Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China, lxflying@aliyun.com.

Oncotargets and Therapy
|February 19, 2019
PubMed

Insights

MicroRNA-124 (miR-124) is a key player in colorectal cancer, acting as a tumor suppressor. Methylation of miR-124 during cancer development suggests its potential as a diagnostic biomarker and therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Colorectal cancer (CRC) is a significant global health concern.
  • MicroRNAs (miRNAs) are increasingly recognized for their roles in cancer development.
  • miR-124 has emerged as a miRNA of interest in CRC research.

Purpose of the Study:

  • To summarize current research on the function and mechanisms of miR-124 in colorectal cancer.
  • To explore the potential of miR-124 as a biomarker and therapeutic target for CRC.

Main Methods:

  • Literature review and synthesis of existing studies on miR-124 in CRC.
  • Analysis of molecular mechanisms, including methylation, associated with miR-124.
  • Evaluation of diagnostic and therapeutic implications.

Main Results:

  • miR-124 is frequently methylated during colorectal cancer carcinogenesis.
  • miR-124 functions as a tumor suppressor in the context of colorectal cancer.
  • Evidence suggests miR-124's involvement in regulating cancer cell behavior.

Conclusions:

  • miR-124 plays a critical role in suppressing colorectal cancer.
  • Methylation-induced downregulation of miR-124 contributes to CRC development.
  • miR-124 holds promise as a future diagnostic biomarker and therapeutic target for colorectal cancer.
Keywords:
biomarkercolorectal cancermethylationmiR-124therapeutic target

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