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Avasimibe inhibits tumor growth by targeting FoxM1-AKR1C1 in osteosarcoma

Liang Wang1, Yang Liu1, Guanzhen Yu2

  • 1Department of Orthopedic, Changzheng Hospital, Shanghai 200003, China.

Oncotargets and Therapy
|February 19, 2019
PubMed
Abstract

Insights

High AKR1C1 expression in osteosarcoma (OS) correlates with poor outcomes. Targeting AKR1C1 with avasimibe shows promise for treating this bone cancer by inhibiting tumor growth.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Osteosarcoma (OS) is a rare bone cancer characterized by high rates of lung metastasis and poor patient prognosis.
  • Identifying novel therapeutic targets and prognostic biomarkers is critical for improving outcomes in OS patients.

Purpose of the Study:

  • To investigate the role of Aldo-keto Reductase Family 1 Member C1 (AKR1C1) as a prognostic factor in osteosarcoma.
  • To evaluate the therapeutic potential of avasimibe, an AKR1C1 inhibitor, in osteosarcoma treatment.

Main Methods:

  • AKR1C1 protein expression levels were assessed in osteosarcoma specimens.
  • The clinical significance of AKR1C1 expression was correlated with patient outcomes.
  • In vitro and in vivo studies were conducted using avasimibe to target AKR1C1 in osteosarcoma models.

Main Results:

  • Elevated AKR1C1 expression was significantly observed in osteosarcoma tissues.
  • High AKR1C1 expression was associated with poorer clinical outcomes in patients with osteosarcoma.
  • Avasimibe treatment effectively inhibited osteosarcoma cell proliferation and tumor growth, accompanied by reduced expression of AKR1C1 and FoxM1.

Conclusions:

  • AKR1C1 serves as a potential prognostic biomarker for osteosarcoma.
  • Targeting AKR1C1 with avasimibe represents a promising novel therapeutic strategy for human osteosarcoma.
Keywords:
AKR1C1FoxM1immunohistochemistryosteosarcoma

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