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Related Concept Videos

Ankle Joint01:10

Ankle Joint

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The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
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What is Natural Selection?01:32

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Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
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Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
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When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
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Related Experiment Video

Updated: Jan 29, 2026

Reverse Total Shoulder Arthroplasty
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Patient selection for total ankle arthroplasty.

Laurens W van der Plaat1, Daniël Haverkamp2

  • 1Department of Orthopaedic Surgery, Noordwest Ziekenhuisgroep, Alkmaar, the Netherlands, lplaat@hotmail.com.

Orthopedic Research and Reviews
|February 19, 2019
PubMed
Summary

Patient selection is crucial for successful total ankle replacement (TAR) outcomes in ankle osteoarthritis. This review examines how patient characteristics impact TAR results and survival rates.

Keywords:
ankle arthrodesisankle prosthesiscontraindicationspatient characteristicstotal ankle arthroplasty

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Area of Science:

  • Orthopedics
  • Surgical Innovation
  • Biomedical Engineering

Background:

  • End-stage ankle osteoarthritis necessitates surgical intervention, with total ankle arthroplasty (TAR) and ankle arthrodesis as primary options.
  • Clinical outcomes and implant survival in TAR are influenced by numerous factors, notably patient-specific characteristics.
  • Optimal patient selection is widely recognized as a critical determinant for achieving favorable and enduring results after total ankle replacement.

Purpose of the Study:

  • To systematically review and synthesize existing scientific evidence on the impact of patient characteristics on total ankle arthroplasty outcomes.
  • To identify key patient variables that influence the success and longevity of total ankle replacement procedures.
  • To provide a comprehensive overview for surgeons regarding patient selection criteria in TAR.

Main Methods:

  • Literature search of scientific databases for studies investigating patient characteristics and TAR outcomes.
  • Inclusion of peer-reviewed articles reporting on clinical results, survival rates, and patient-reported outcomes.
  • Synthesis of evidence from diverse patient populations and study designs.

Main Results:

  • Specific patient demographics, comorbidities, and lifestyle factors have been associated with varying degrees of success in TAR.
  • Evidence suggests certain patient profiles may experience higher risks of complications or revision surgery after total ankle replacement.
  • The influence of factors like age, body mass index, and activity level on TAR outcomes is consistently reported across studies.

Conclusions:

  • Patient selection is paramount for optimizing total ankle arthroplasty outcomes and minimizing revision rates.
  • A thorough understanding of how patient characteristics affect TAR results is essential for informed surgical decision-making.
  • Further research is warranted to refine patient selection criteria and improve long-term success for total ankle replacement.