Related Experiment Video

Updated: Jan 29, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K

Metabolic Acidosis of Chronic Kidney Disease and Cardiovascular Disorders

Simona Stancu1, Gabriel Mircescu1, Andreea Mocanu2

  • 1Nephrology Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Maedica
|February 19, 2019
PubMed

Insights

Chronic kidney disease (CKD) significantly increases cardiovascular disease (CVD) risk, potentially due to metabolic acidosis. This review examines the controversial link between CKD-induced metabolic acidosis and CVD.

Area of Science:

  • Nephrology
  • Cardiology
  • Internal Medicine

Background:

  • Growing global burden of chronic diseases, including cardiovascular diseases (CVD) and chronic kidney disease (CKD).
  • Recognized bidirectional relationship between kidney and heart disorders, with complex underlying pathogenesis.
  • CKD patients exhibit a markedly higher prevalence of CVD (up to 30x) compared to the general population.

Purpose of the Study:

  • To summarize current knowledge on the influence of metabolic acidosis in advanced CKD on CVD.
  • To highlight existing controversies and points of debate regarding this association.

Main Methods:

  • Review of epidemiological studies and medical literature.
  • Analysis of non-traditional cardiovascular risk factors in CKD.
  • Focus on metabolic acidosis as a potential contributing factor to CVD in CKD.

Main Results:

  • Metabolic acidosis is a frequent complication of advanced CKD.
  • Conflicting results exist regarding the direct impact of metabolic acidosis on CVD development in CKD patients.
  • Traditional risk factors do not fully explain the elevated CVD prevalence in CKD.

Conclusions:

  • The role of CKD-related metabolic acidosis as a non-traditional CVD risk factor remains controversial.
  • Further research is needed to elucidate the precise mechanisms linking metabolic acidosis and CVD in CKD.
  • Understanding these interactions is crucial for managing patients with both conditions.

More Related Videos

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.4K
In Silico Clinical Trials for Cardiovascular Disease09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.2K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
702
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
617
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
390
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
368
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
475
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
785