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Neonatal sepsis due to glycopeptide resistant Enterococcus faecium from colonized maternal gut- rare case evidence

Supram Hosuru Subramanya1, Rajesh Amberpet2,3, Dinesh Chaudhary1

  • 11Department of Medical Microbiology, Manipal College of Medical Sciences, Pokhara, Nepal.

Antimicrobial Resistance and Infection Control
|February 19, 2019
PubMed

Insights

Maternal gut colonization by vancomycin-resistant Enterococcus faecium (VRE) caused neonatal septicemia. This case highlights the need for maternal VRE screening to prevent infant infections.

Area of Science:

  • Neonatal Intensive Care Unit (NICU) infections
  • Antimicrobial resistance
  • Infectious disease epidemiology

Background:

  • Vancomycin-resistant enterococcal (VRE) infections pose a growing global threat, particularly in neonatal intensive care units (NICUs).
  • This report details a case of neonatal septicemia caused by multidrug-resistant VRE originating from the mother's gut.

Observation:

  • A newborn diagnosed with septicemia and bacteremia was found to be infected with multidrug-resistant VRE.
  • Screening identified VRE in both the infant and the mother, with identical genetic profiles (antibiogram, vanA gene, PFGE).

Findings:

  • Maternal gut colonization was confirmed as the source of neonatal VRE sepsis.
  • The infant successfully responded to a one-week course of oral linezolid, with VRE eradication confirmed by repeat stool cultures.

Implications:

  • Implementing optimal infection control measures in NICUs is essential.
  • Developing guidelines for monitoring VRE colonization in pregnant women could help reduce neonatal sepsis cases.
Abstract

Keywords:
Gut colonizationNeonatal SepsisVRE

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