Effects of L-lysine·H₂SO₄ product on the intestinal morphology and liver pathology using broiler model

Lysine is used widely in livestock production due to the shortage of feed protein resources. L-lysine·H₂SO₄ contains L-lysine sulphate as well as fermentation co-products which contain other amino acids and phosphorus. However, there are few articles about L-lysine·H₂SO₄ product regarding intestinal morphology and liver pathology of broiler chickens. In this article, we focus on the absorption and metabolism of L-lysine·H₂SO₄ revealed in the variation of intestinal morphology and liver pathology to determine the tolerance of chicks for L-lysine·H₂SO₄.

To evaluate the tolerance of broilers for L-lysine·H₂SO₄, 240 one day old broilers were allocated randomly to one of five dietary treatments which included corn-soybean diets containing 0, 1%, 4%, 7% or 10% L-lysine·H₂SO₄ (L-lysine content = 55%).

Supplementation of 1% L-lysine·H₂SO₄ in the diet had no negative effects. However, 4%, 7% or 10% L-lysine·H₂SO₄ supplementation produced negative responses on broiler performance, carcass characteristics, blood biochemistry, and particularly on intestinal morphology and liver pathology compared with broilers fed the control diet.

Our results show that supplementation with 1% L-lysine·H₂SO₄ had no negative effects on performance, carcass characteristics, blood biochemistry, intestinal morphology and liver pathology in broilers, but supplementation with 4%, 7% or 10% L-lysine·H₂SO₄ produced a negative response, particularly with respect to intestinal morphology and liver pathology.