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Updated: Jan 29, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Expanding the Spectrum of Light-Driven Peroxygenase Reactions
Sébastien J-P Willot1, Elena Fernández-Fueyo1, Florian Tieves1
1Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Abstract:
Peroxygenases require a controlled supply of H2O2 to operate efficiently. Here, we propose a photocatalytic system for the reductive activation of ambient O2 to produce H2O2 which uses the energy provided by visible light more efficiently based on the combination of wavelength-complementary photosensitizers. This approach was coupled to an enzymatic system to make formate available as a sacrificial electron donor. The scope and current limitations of this approach are reported and discussed.
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