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Planning, Implementing, and Running a Multicentre Preterm Birth Study with Biobank Resources in Brazil: The Preterm

Renato T Souza1, Jose G Cecatti1, Maria L Costa1

  • 1Department of Obstetrics and Gynecology, University of Campinas (UNICAMP), School of Medical Sciences, Campinas, SP, Brazil.

Biomed Research International
|February 19, 2019
PubMed

Insights

This study details the planning and execution of the Preterm SAMBA multicentre cohort study in Brazil, focusing on identifying preterm birth risk using a maternal biobank. Lessons learned offer valuable insights for future reproductive and perinatal health research.

Area of Science:

  • Reproductive Health
  • Perinatal Epidemiology
  • Biobanking

Background:

  • The Preterm SAMBA study, a multicentre cohort, was established in Brazil to investigate maternal and perinatal health.
  • It utilized a high-quality biobank of maternal serum, plasma, and hair samples across five Brazilian sites.
  • The study aimed to identify women at higher risk for preterm birth and other complications in a middle-income country context.

Purpose of the Study:

  • To describe the comprehensive planning, implementation, and operational phases of the Preterm SAMBA multicentre cohort study.
  • To validate metabolite biomarkers for preterm birth prediction in a Brazilian cohort of low-risk nulliparous pregnant women.
  • To document strategies and address barriers encountered during the study for future research guidance.

Main Methods:

  • Detailed description of the planning, implementation, and maintenance procedures for a multicentre cohort study.
  • Inclusion of low-risk nulliparous pregnant women for biomarker validation.
  • Emphasis on strategies and resources developed by the Brazilian Network for Studies on Reproductive and Perinatal Health.

Main Results:

  • Identification of various barriers and successful strategies across different study levels (steering committee, coordinating, and local centers).
  • Highlighting the role of the Brazilian Network's legacy in training collaborators for complex research settings.
  • Demonstration of effective resource utilization and collaborative approaches in multicentre research.

Conclusions:

  • The Brazilian Network has gained significant experience in conducting multicentre cohort studies with biobanks.
  • This experience provides a valuable resource for other research groups planning similar maternal and perinatal health studies.
  • The study's findings and methodologies can inform the development of future reproductive and perinatal health research networks.
Abstract

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