Related Experiment Videos
Comparative sensitivity of the MoCA and Mattis Dementia Rating Scale-2 in Parkinson's disease
Taylor R Hendershott1, Delphine Zhu2, Seoni Llanes2
1Department of Psychological and Brain Sciences, Washington University, St. Louis, Missouri, USA.
Background:
Clinicians and researchers commonly use global cognitive assessments to screen for impairment. Currently there are no published studies directly comparing the sensitivity and specificity of the Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 in PD. The objective of this study was to identify the relative sensitivity and specificity of the Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 in PD.
Methods:
The Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 were administered to training and validation cohorts. Cutoff scores were determined within the training cohort (n = 85) to optimize sensitivity and specificity for cognitive impairment and were applied to an independent validation cohort (n = 521).
Results:
The Montreal Cognitive Assessment was consistently sensitive across training and validation cohorts (90.0% and 80.3%, respectively), whereas the Mattis Dementia Rating Scale-2 was not (87.5% and 60.3%, respectively). In individual domains, the Montreal Cognitive Assessment remained sensitive to memory and visuospatial impairments (91.9% and 87.8%, respectively), whereas the Mattis Dementia Rating Scale-2 was sensitive to executive impairments (86.2%).
Conclusion:
The Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 demonstrated individual strengths. Future work should focus on developing domain-specific cognitive screening tools for PD. © 2018 International Parkinson and Movement Disorder Society.
Insights
The Montreal Cognitive Assessment (MoCA) is more sensitive than the Mattis Dementia Rating Scale-2 for detecting cognitive impairment in Parkinson's disease (PD). Further research should explore domain-specific screening tools for PD.
Area of Science:
- Neurology
- Cognitive Science
- Geriatrics
Background:
- Global cognitive assessments are vital for screening cognitive impairment in clinical practice and research.
- No prior studies directly compared the sensitivity and specificity of MoCA and MDSR-2 in Parkinson's disease (PD).
Purpose of the Study:
- To determine the relative sensitivity and specificity of the MoCA and MDSR-2 for identifying cognitive impairment in PD patients.
Main Methods:
- The MoCA and MDSR-2 were administered to independent training (n=85) and validation (n=521) cohorts.
- Optimal cutoff scores for cognitive impairment were established using the training cohort and validated on the larger cohort.
Main Results:
- The MoCA demonstrated higher and consistent sensitivity (90.0% training, 80.3% validation) compared to the MDSR-2 (87.5% training, 60.3% validation).
- MoCA excelled in detecting memory and visuospatial deficits, while MDSR-2 was more sensitive to executive dysfunction.
Conclusions:
- Both MoCA and MDSR-2 show unique strengths in assessing cognitive domains in PD.
- Future research should prioritize developing specialized, domain-specific cognitive screening instruments tailored for PD.