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Cost-Effectiveness Comparison of Pneumococcal Conjugate Vaccines in Turkish Children

Alen Marijam1, Jan Olbrecht1, Alev Ozakay2

  • 1GSK, Wavre, Belgium.

Value in Health Regional Issues
|February 19, 2019
PubMed

Insights

Replacing the 13-valent pneumococcal conjugate vaccine (PCV13) with the pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in Turkey is cost-effective. At equal prices, PHiD-CV is a dominant strategy, reducing acute otitis media cases and saving costs.

Area of Science:

  • Public Health
  • Vaccinology
  • Health Economics

Background:

  • The 13-valent pneumococcal conjugate vaccine (PCV13) is currently used for universal infant immunization in Turkey.
  • Pneumococcal conjugate vaccines are crucial for preventing invasive pneumococcal disease, pneumonia, and acute otitis media (AOM) in children.

Purpose of the Study:

  • To evaluate the cost-effectiveness of substituting PCV13 with the pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in Turkey.
  • To compare the health and economic impacts of PHiD-CV versus PCV13 for preventing pneumococcal diseases in infants.

Main Methods:

  • A Markov cohort model simulated the outcomes for a cohort of infants over a 10-year period.
  • Local epidemiological and economic data were incorporated, with a 3% annual discount rate applied to costs and benefits.
  • The model assessed the impact on invasive pneumococcal disease, pneumonia, and AOM, including healthcare resource utilization.

Main Results:

  • PHiD-CV demonstrated comparable effectiveness to PCV13 for meningitis and pneumonia, with a slight increase in bacteremia cases (+30).
  • PHiD-CV led to significant reductions in AOM-related general practitioner visits (-34,955) and hospitalizations (-624).
  • At price parity, PHiD-CV was found to be a dominant strategy, yielding 176 additional quality-adjusted life-years and saving €635,930.

Conclusions:

  • Vaccine price is the primary determinant for choosing between PHiD-CV and PCV13 in Turkey.
  • PHiD-CV represents a dominant and cost-effective strategy compared to PCV13 when vaccine prices are equal.
  • The findings support the consideration of PHiD-CV for national immunization programs to optimize health outcomes and economic efficiency.
Abstract

Keywords:
Turkeychildrencost-effectiveness analysispneumococcal vaccine

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