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Updated: Jan 29, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Functionalized photosensitive gelatin nanoparticles for drug delivery application
Janicy Arantes Carvalho1, Alexandro da Silva Abreu1, Antonio Claudio Tedesco2
1a Organic Synthesis Laboratory , Research and Development Institute - IPD Vale do Paraíba University , São José dos Campos , Brazil.
Abstract:
In this study, zinc phthalocyanine (ZnPc) was loaded onto gelatin nanoparticles functionalized with polyelectrolytes (polystyrene sulfonate/polyallylamine hydrochloride) by layer-by-layer (LbL) assembly. The process yield and the encapsulation efficiency were 76.0% ± 2.5 and 86.0% ± 1.8, respectively. The functionalized photosensitive gelatin nanoparticles (FPGN) had a mean diameter of 396.5 ± 45.8 nm, narrow distribution size with a polydispersity index of 0.106. The obvious switching of zeta potential indicates successful alternating deposition of the polyanion PSS and polycation PAH directly on the gelatin nanoparticles. The in vitro drug release investigation found that the LbL deposited polyelectrolyte bilayer is very efficient to reduce the release rate and assuage the initial burst for drugs loaded in gelatin nanoparticles. The photobiological activity of FPGN was evaluated on mouse macrophage carcinoma line J774 A-1. The cells viability decreased with the increase of the light dose in the range of 1-10.0 J.cm-2. ZnPc-loaded in functionalized gelatin nanoparticles are the release systems that promise photodynamic therapy use.
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