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Risk factors of early childhood caries (ECC) among children in Beijing - a prospective cohort study
Can Can Fan1,2, Wen Hui Wang1, Tao Xu3
1Department of Preventive Dentistry, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing, 100081, People's Republic of China.
Insights
High plaque mutans streptococci levels are a key risk factor for early childhood caries (ECC) in preschool children. Previous caries experience also significantly contributes to ECC development in this population.
Area of Science:
- Pediatric Dentistry
- Oral Microbiology
- Public Health
Background:
- Early childhood caries (ECC) presents a significant oral health challenge in China, characterized by high prevalence and low treatment rates.
- Research specifically addressing ECC in preschool children remains limited.
- This study investigated the risk factors associated with ECC in preschool children in Beijing, China.
Purpose of the Study:
- To identify and analyze the risk factors contributing to the development of early childhood caries (ECC) in a cohort of preschool children.
- To provide data for targeted prevention and intervention strategies for ECC in this age group.
Main Methods:
- A prospective cohort study involving 712 children (mean age 46.37 months).
- Data collection included baseline questionnaires, plaque and saliva mutans streptococci (MS) levels (Dentocult SM strips), and dental caries assessment (WHO 1997 criteria).
- Multivariate analysis using negative binomial regression was employed to identify factors related to caries development over a 1-year follow-up period.
Main Results:
- For caries-free children at baseline, elevated plaque mutans streptococci (PMS) levels were the sole significant predictor of caries development (OR=1.68, P=0.02).
- Children with high PMS levels exhibited higher caries incidence (46.2%) and greater caries increment (1.87) compared to those with low PMS levels.
- Across all participants, both high PMS levels (OR=1.69, P<0.001) and prior caries experience (OR=2.80, P<0.001) were significantly associated with caries increment.
Conclusions:
- High plaque mutans streptococci levels are a critical risk factor for early childhood caries in previously caries-free preschool children.
- In the overall preschool population, both high plaque mutans streptococci levels and previous caries experience are significant risk factors for caries development.
Background:
Early childhood caries (ECC) was a serious oral health concern with high prevalence and a low treatment rate in China, and few researches have focused on preschool children. This study aimed to explore the risk factors of ECC in Beijing, China.
Methods:
Totle of 712 children (mean age: 46.37 ± 5.44 months) participated in this prospective cohort study. Questionnaires and the levels of mutans streptococci in dental plaques and non-stimulated saliva, assessed using Dentocult SM strips, were collected at baseline, respectively. Two calibrated examiners checked for dental caries according to the WHO 1997 criteria at baseline and 1-year follow-up. Negative binomial regression was used for multivariate analysis of factors related to caries development.
Results:
For caries-free children at baseline, only plaque mutans streptococci (PMS) levels were associated with caries development (odds ratio [OR] = 1.68, 95% confidence interval [CI]: 1.08-2.61, P = 0.02). Children with high PMS levels (scored 2 and 3) had higher caries incidence (46.2% vs. 33.8%) and more caries increment (1.87 ± 3.17 vs. 0.90 ± 1.89) than those with low levels (scored 0 and 1). Among all participants, PMS (OR = 1.69, 95% CI: 1.32-2.23, P < 0.001) and previous caries experience (OR = 2.80, 95% CI: 2.20-3.56, P < 0.001) were related to caries increment.
Conclusions:
For caries-free children, the only significant risk factor for ECC was high PMS levels. For all participants, besides high PMS levels, previous caries experience was another significant risk factor for caries development.
Trial Registration:
The study design, protocol, and informed consent forms were undertaken with the understanding of Declaration of Helsinki and were approved by the Human Research Ethics Committee of the School of Stomatology, Peking University, China (PKUSSIRB-2012042).
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