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Updated: Jan 29, 2026
09:12
A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
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High 30-day readmission rates associated with Clostridiumdifficile infection
Elijah Verheyen1, Vijay Dalapathi2, Shilpkumar Arora3
1Department of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai West-St. Luke's Hospital, New York, NY.
American Journal of Infection Control
|February 20, 2019
Summary
Nearly one in five patients hospitalized with Clostridium difficile infection (CDI) are readmitted within 30 days. Infections, particularly recurrent CDI, drive these readmissions, with female sex and comorbidities being key predictors.
Area of Science:
- Infectious Diseases
- Healthcare Epidemiology
- Patient Outcomes
Background:
- Clostridium difficile infection (CDI) is a significant cause of community- and healthcare-associated infections.
- High recurrence rates, morbidity, and mortality are characteristic of CDI.
- Understanding readmission patterns is crucial for managing CDI.
Purpose of the Study:
- To determine national rates of hospital readmission for CDI.
- To identify the leading causes of CDI readmissions.
- To pinpoint predictors associated with CDI readmission.
Main Methods:
- Retrospective analysis of the 2013 Nationwide Readmissions Database.
- Inclusion of patients with a primary CDI diagnosis and 30-day readmission.
- Application of a multivariate regression model to identify readmission predictors.
Main Results:
- 21% of 38,409 CDI patients were readmitted within 30 days.
- Infections accounted for 47% of readmissions, with CDI being the most frequent cause.
- Predictors of readmission included female sex, anemia, renal failure, and discharge to home.
Conclusions:
- One in five hospitalized CDI patients experience 30-day readmission.
- Infections are the primary driver of readmissions, with CDI being the most common.
- Female sex, renal failure, anemia, and home discharge are significant predictors of CDI readmission.
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