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Extragonadal FSHR Expression and Function-Is It Real?

Marcin Chrusciel1, Donata Ponikwicka-Tyszko2, Slawomir Wolczynski2,3

  • 1Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.

Frontiers in Endocrinology
|February 20, 2019
PubMed

Insights

Follicle-stimulating hormone receptor (FSHR) expression is reported in extragonadal tissues, but findings require validation. This review critically analyzes evidence and proposes methods for confirming FSHR

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Follicle-stimulating hormone receptor (FSHR) expression is increasingly reported in extragonadal tissues, including cancers.
  • Suggested extragonadal FSH actions include promoting angiogenesis and adipose tissue accumulation.
  • Potential roles for FSHR in cancer diagnostics, prognostics, and therapeutics are proposed.

Purpose of the Study:

  • To critically analyze existing literature on extragonadal FSHR expression and FSH actions.
  • To identify methodological limitations and discrepancies in current research.
  • To propose a rationale for validating reported findings using rigorous methods.

Main Methods:

  • Critical review of published studies on extragonadal FSHR expression.
  • Analysis of immunohistochemistry (IHC) validation and antibody usage.
  • Assessment of gene expression data versus protein expression findings.
  • Evaluation of in vitro study limitations regarding FSH dosage.

Main Results:

  • Concerns exist regarding the validity of FSHR detection methods, particularly antibody usage and validation.
  • Discrepancies noted between gene/transcript data and protein expression levels.
  • High-dose recombinant FSH used in in vitro studies may limit physiological relevance.

Conclusions:

  • Current evidence for extragonadal FSHR expression and function requires critical re-evaluation.
  • Methodological rigor, including proper controls and validation, is essential.
  • Further research using validated methods and in vivo models is needed to confirm findings.
Keywords:
FSHFSHRcancer cellsextragonadal expressiontumor vessel cells

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