Related Experiment Video
Updated: Jan 29, 2026
10:59
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
Published on: February 7, 2025
1.8K
The minimum information required for a glycomics experiment (MIRAGE) project: LC guidelines
Matthew P Campbell1, Jodie L Abrahams1, Erdmann Rapp2
1Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.
Glycobiology
|February 20, 2019
Summary
New guidelines improve reporting for liquid chromatography (LC) glycan data. These Minimum Information Required for a Glycomics Experiment (MIRAGE) standards enhance reproducibility in glycobiology research.
Area of Science:
- Glycomics
- Glycobiology
- Analytical Chemistry
Background:
- Reproducibility in glycomics research is crucial for advancing scientific understanding.
- Existing reporting standards for glycan analysis are insufficient, particularly for liquid chromatography (LC) data.
- The Minimum Information Required for a Glycomics Experiment (MIRAGE) initiative aims to standardize reporting practices.
Purpose of the Study:
- To introduce the first version of guidelines for reporting liquid chromatography (LC) glycan data.
- To improve the quality and consistency of LC glycan data reporting in scientific literature.
- To ensure better reproducibility of glycomics experiments utilizing LC.
Main Methods:
- Development of comprehensive guidelines covering instrument setup for LC glycan analysis.
- Inclusion of recommendations for data handling and manipulation in LC glycomics.
- Cross-linking with existing MIRAGE recommendations for a holistic approach.
Main Results:
- Establishment of standardized guidelines for LC glycan data reporting.
- A framework provided to researchers for detailed and accurate reporting of their methods.
- Enhanced clarity and comparability of LC-based glycomics studies.
Conclusions:
- The MIRAGE-LC guidelines represent a significant step towards standardized reporting in glycomics.
- Adoption of these guidelines will improve data quality and experimental reproducibility.
- These guidelines are essential for the advancement of the field of glycoanalytics.
Related Concept Videos
02:18Fischer Projections
16.5K
Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
16.5K
02:06Newman Projections
20.8K
Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
20.8K
01:26Requirements for Human Life
13.5K
The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
13.5K
01:11Guidelines for Writing Outcome
3.8K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.8K
01:30Guidelines for Nursing Documentation I
1.8K
Quality documentation and reporting share essential characteristics that ensure they are practical and valuable resources for those who use them. These characteristics are:
Factual:
The following points emphasize the significance of upholding accurate and unbiased documentation in healthcare.
Factual:
The following points emphasize the significance of upholding accurate and unbiased documentation in healthcare.
1.8K
01:23Guidelines for Sketching a Curve
120
Curve sketching is a systematic method for understanding the overall behavior of a function by analyzing its key mathematical features. A function defines a curve on the coordinate plane, where the horizontal axis represents the input variable and the vertical axis represents the output. The process begins by determining the domain, which specifies the set of input values for which the function is defined and establishes the horizontal extent of the graph.Intercepts with the horizontal and...
120